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STRINGSTRING
GAD2 GAD2 CRK CRK GAD1 GAD1 ALDH5A1 ALDH5A1 MIB1 MIB1 MIB2 MIB2 UPB1 UPB1 DDC DDC CARNS1 CARNS1 SGPL1 SGPL1 EHHADH EHHADH HDC HDC ABAT ABAT HADH HADH GADL1 GADL1 ALDH6A1 ALDH6A1 AOX1 AOX1 HIBADH HIBADH CSAD CSAD MIER3 MIER3 SEPSECS SEPSECS LGR4 LGR4 BAG3 BAG3 MRGBP MRGBP DMAP1 DMAP1 MIER1 MIER1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
EHHADHenoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (723 aa)
GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA (585 aa)
MIB1mindbomb E3 ubiquitin protein ligase 1 (1006 aa)
HIBADH3-hydroxyisobutyrate dehydrogenase (336 aa)
CSADcysteine sulfinic acid decarboxylase (520 aa)
HDChistidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine (662 aa)
ABAT4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine (500 aa)
GADL1glutamate decarboxylase-like 1 (521 aa)
CRKv-crk sarcoma virus CT10 oncogene homolog (avian); The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling (304 aa)
DMAP1DNA methyltransferase 1 associated protein 1; Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX- mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucl [...] (467 aa)
ALDH5A1aldehyde dehydrogenase 5 family, member A1; Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) (548 aa)
UPB1ureidopropionase, beta; Converts N-carbamyl-beta-aminoisobutyric acid and N- carbamyl-beta-alanine to, respectively, beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide (384 aa)
DDCdopa decarboxylase (aromatic L-amino acid decarboxylase); Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine (480 aa)
GAD1glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA (594 aa)
BAG3BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity (575 aa)
MRGBPMRG/MORF4L binding protein; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative [...] (204 aa)
SGPL1sphingosine-1-phosphate lyase 1; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (568 aa)
AOX1aldehyde oxidase 1 (1338 aa)
LGR4leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor (951 aa)
MIER3mesoderm induction early response 1, family member 3; Transcriptional repressor (By similarity) (549 aa)
SEPSECSSep (O-phosphoserine) tRNA-Sec (selenocysteine) tRNA synthase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis (501 aa)
MIER1mesoderm induction early response 1 homolog (Xenopus laevis) (565 aa)
HADHhydroxyacyl-CoA dehydrogenase; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA (331 aa)
CARNS1carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine (950 aa)
MIB2mindbomb E3 ubiquitin protein ligase 2 (1070 aa)
ALDH6A1aldehyde dehydrogenase 6 family, member A1; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (535 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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