node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CALCOCO2 | UBC | ENSP00000258947 | ENSP00000344818 | calcium binding and coiled-coil domain 2; May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion | ubiquitin C | 0.987 |
CEP57 | TUBGCP3 | ENSP00000317902 | ENSP00000261965 | centrosomal protein 57kDa; Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring- like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1 | tubulin, gamma complex associated protein 3; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome | 0.900 |
CEP57 | UBC | ENSP00000317902 | ENSP00000344818 | centrosomal protein 57kDa; Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring- like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1 | ubiquitin C | 0.721 |
CPNE7 | OTUB1 | ENSP00000268720 | ENSP00000402551 | copine VII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | OTU domain, ubiquitin aldehyde binding 1; Hydrolase that can specifically remove ’Lys-48’-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes a [...] | 0.748 |
CPNE7 | USP53 | ENSP00000268720 | ENSP00000274030 | copine VII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | ubiquitin specific peptidase 53; Has no peptidase activity | 0.742 |
CPNE7 | UVRAG | ENSP00000268720 | ENSP00000348455 | copine VII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | UV radiation resistance associated | 0.592 |
OTUB1 | CPNE7 | ENSP00000402551 | ENSP00000268720 | OTU domain, ubiquitin aldehyde binding 1; Hydrolase that can specifically remove ’Lys-48’-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes a [...] | copine VII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | 0.748 |
OTUB1 | UBC | ENSP00000402551 | ENSP00000344818 | OTU domain, ubiquitin aldehyde binding 1; Hydrolase that can specifically remove ’Lys-48’-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes a [...] | ubiquitin C | 0.999 |
TUBGCP3 | CEP57 | ENSP00000261965 | ENSP00000317902 | tubulin, gamma complex associated protein 3; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome | centrosomal protein 57kDa; Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring- like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1 | 0.900 |
TUBGCP3 | UBC | ENSP00000261965 | ENSP00000344818 | tubulin, gamma complex associated protein 3; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome | ubiquitin C | 0.859 |
UBC | CALCOCO2 | ENSP00000344818 | ENSP00000258947 | ubiquitin C | calcium binding and coiled-coil domain 2; May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion | 0.987 |
UBC | CEP57 | ENSP00000344818 | ENSP00000317902 | ubiquitin C | centrosomal protein 57kDa; Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring- like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1 | 0.721 |
UBC | OTUB1 | ENSP00000344818 | ENSP00000402551 | ubiquitin C | OTU domain, ubiquitin aldehyde binding 1; Hydrolase that can specifically remove ’Lys-48’-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes a [...] | 0.999 |
UBC | TUBGCP3 | ENSP00000344818 | ENSP00000261965 | ubiquitin C | tubulin, gamma complex associated protein 3; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome | 0.859 |
UBC | UVRAG | ENSP00000344818 | ENSP00000348455 | ubiquitin C | UV radiation resistance associated | 0.509 |
USP53 | CPNE7 | ENSP00000274030 | ENSP00000268720 | ubiquitin specific peptidase 53; Has no peptidase activity | copine VII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | 0.742 |
UVRAG | CPNE7 | ENSP00000348455 | ENSP00000268720 | UV radiation resistance associated | copine VII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | 0.592 |
UVRAG | UBC | ENSP00000348455 | ENSP00000344818 | UV radiation resistance associated | ubiquitin C | 0.509 |