Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
USP53 USP53 CPNE7 CPNE7 ADAMTSL4 ADAMTSL4 UVRAG UVRAG OTUB1 OTUB1 UBC UBC CALCOCO2 CALCOCO2 CEP57 CEP57 TUBGCP3 TUBGCP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
CALCOCO2calcium binding and coiled-coil domain 2; May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion (446 aa)
TUBGCP3tubulin, gamma complex associated protein 3; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome (907 aa)
CPNE7copine VII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) (633 aa)
ADAMTSL4ADAMTS-like 4; Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis (1074 aa)
USP53ubiquitin specific peptidase 53; Has no peptidase activity (1073 aa)
CEP57centrosomal protein 57kDa; Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring- like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1 (500 aa)
UBCubiquitin C (685 aa)
UVRAGUV radiation resistance associated (699 aa)
OTUB1OTU domain, ubiquitin aldehyde binding 1; Hydrolase that can specifically remove ’Lys-48’-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes a [...] (271 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (38%)