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ABCC1 ABCC1 ABCC4 ABCC4 ABCB1 ABCB1 CFTR CFTR ABCC5 ABCC5 ABCG2 ABCG2 CBX3 CBX3 ABCB4 ABCB4 ABCC12 ABCC12 ABCC6 ABCC6 ABCB9 ABCB9 ABCC2 ABCC2 ENSG00000250264 ENSG00000250264 TAP1 TAP1 TAP2 TAP2 ABCC10 ABCC10 ABCB10 ABCB10 ABCA8 ABCA8 ABCB11 ABCB11 RPS3 RPS3 ABCC8 ABCC8 ABCC11 ABCC11 ABCC9 ABCC9 ABCB8 ABCB8 ABCB5 ABCB5 ABCC3 ABCC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (1480 aa)
ABCC6ATP-binding cassette, sub-family C (CFTR/MRP), member 6; May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (1503 aa)
ABCG2ATP-binding cassette, sub-family G (WHITE), member 2 (655 aa)
ABCC9ATP-binding cassette, sub-family C (CFTR/MRP), member 9; Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (1549 aa)
ABCB11ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes (1321 aa)
ABCB4ATP-binding cassette, sub-family B (MDR/TAP), member 4; Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte (1286 aa)
ABCB1ATP-binding cassette, sub-family B (MDR/TAP), member 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (1280 aa)
ABCA8ATP-binding cassette, sub-family A (ABC1), member 8; ATP-dependent lipophilic drug transporter (1581 aa)
ABCB9ATP-binding cassette, sub-family B (MDR/TAP), member 9; ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored (766 aa)
ABCC3ATP-binding cassette, sub-family C (CFTR/MRP), member 3 (1527 aa)
ABCC12ATP-binding cassette, sub-family C (CFTR/MRP), member 12; Probable transporter (By similarity) (1359 aa)
ABCC5ATP-binding cassette, sub-family C (CFTR/MRP), member 5 (1437 aa)
CBX3chromobox homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at ’Lys-9’, leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (183 aa)
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) (808 aa)
ABCC11ATP-binding cassette, sub-family C (CFTR/MRP), member 11; Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycochola [...] (1382 aa)
ABCB8ATP-binding cassette, sub-family B (MDR/TAP), member 8 (718 aa)
ABCB10ATP-binding cassette, sub-family B (MDR/TAP), member 10; May mediate critical mitochondrial transport functions related to heme biosynthesis (By similarity) (738 aa)
ABCC2ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter (1545 aa)
ABCC10ATP-binding cassette, sub-family C (CFTR/MRP), member 10; ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion (1492 aa)
TAP2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) (653 aa)
ABCC4ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification (1325 aa)
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 8; Putative subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release (1581 aa)
ABCC1ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (1531 aa)
ABCB5ATP-binding cassette, sub-family B (MDR/TAP), member 5 (1257 aa)
ENSG00000250264Uncharacterized protein (843 aa)
RPS3ribosomal protein S3 (243 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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