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ESR1 | estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial [...] (595 aa) | |||
SLC30A3 | solute carrier family 30 (zinc transporter), member 3; Involved in accumulation of zinc in synaptic vesicles (By similarity) (388 aa) | |||
SLC30A4 | solute carrier family 30 (zinc transporter), member 4; Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment (429 aa) | |||
DNAJC10 | DnaJ (Hsp40) homolog, subfamily C, member 10 (793 aa) | |||
CP | ceruloplasmin (ferroxidase); Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity) (1065 aa) | |||
SLC39A6 | solute carrier family 39 (zinc transporter), member 6; May act as a zinc-influx transporter (755 aa) | |||
SLC39A3 | solute carrier family 39 (zinc transporter), member 3; Acts as a zinc-influx transporter (Potential) (314 aa) | |||
PDIA4 | protein disulfide isomerase family A, member 4 (645 aa) | |||
SLC39A2 | solute carrier family 39 (zinc transporter), member 2; Mediates zinc uptake. Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis (309 aa) | |||
SLC39A1 | solute carrier family 39 (zinc transporter), member 1; Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells (324 aa) | |||
PGR | progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation (933 aa) | |||
SLC30A7 | solute carrier family 30 (zinc transporter), member 7; Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc- requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity) (376 aa) | |||
ETS2 | v-ets erythroblastosis virus E26 oncogene homolog 2 (avian); Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription (469 aa) | |||
SLC30A10 | solute carrier family 30, member 10; May be involved in zinc transport out of the cell, being a zinc-efflux transporter (By similarity) (485 aa) | |||
SLC30A1 | solute carrier family 30 (zinc transporter), member 1; May be involved in zinc transport out of the cell (507 aa) | |||
KDM5B | lysine (K)-specific demethylase 5B; Histone demethylase that demethylates ’Lys-4’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-9’ or H3 ’Lys-27’. Demethylates trimethylated, dimethylated and monomethylated H3 ’Lys-4’. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma (1544 aa) | |||
SLC30A2 | solute carrier family 30 (zinc transporter), member 2 (372 aa) | |||
TNFRSF9 | tumor necrosis factor receptor superfamily, member 9; Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation (255 aa) | |||
SLC30A6 | solute carrier family 30 (zinc transporter), member 6; Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment (By similarity) (501 aa) | |||
ETS1 | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian); Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (485 aa) | |||
RPL23 | ribosomal protein L23 (140 aa) | |||
SLC30A5 | solute carrier family 30 (zinc transporter), member 5; Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP (765 aa) | |||
SLC30A8 | solute carrier family 30 (zinc transporter), member 8; Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta- cells (369 aa) | |||
ENSG00000267001 | Uncharacterized protein (105 aa) |