node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AP2M1 | UBC | ENSP00000292807 | ENSP00000344818 | adaptor-related protein complex 2, mu 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a [...] | ubiquitin C | 0.979 |
BMI1 | EZH2 | ENSP00000365851 | ENSP00000320147 | BMI1 polycomb ring finger oncogene; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ’Lys-119’, rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 | enhancer of zeste homolog 2 (Drosophila) | 0.996 |
BMI1 | UBC | ENSP00000365851 | ENSP00000344818 | BMI1 polycomb ring finger oncogene; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ’Lys-119’, rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 | ubiquitin C | 0.979 |
CTSB | CTSL1 | ENSP00000342070 | ENSP00000345344 | cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | cathepsin L1; Important for the overall degradation of proteins in lysosomes | 0.700 |
CTSB | CTSL2 | ENSP00000342070 | ENSP00000259470 | cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | cathepsin L2; Cysteine protease. May have an important role in corneal physiology | 0.685 |
CTSB | UBC | ENSP00000342070 | ENSP00000344818 | cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | ubiquitin C | 0.797 |
CTSL1 | CTSB | ENSP00000345344 | ENSP00000342070 | cathepsin L1; Important for the overall degradation of proteins in lysosomes | cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | 0.700 |
CTSL2 | CTSB | ENSP00000259470 | ENSP00000342070 | cathepsin L2; Cysteine protease. May have an important role in corneal physiology | cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | 0.685 |
EZH2 | BMI1 | ENSP00000320147 | ENSP00000365851 | enhancer of zeste homolog 2 (Drosophila) | BMI1 polycomb ring finger oncogene; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ’Lys-119’, rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 | 0.996 |
EZH2 | UBC | ENSP00000320147 | ENSP00000344818 | enhancer of zeste homolog 2 (Drosophila) | ubiquitin C | 0.948 |
FLT1 | SERPINB12 | ENSP00000282397 | ENSP00000269491 | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | serpin peptidase inhibitor, clade B (ovalbumin), member 12; Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator | 0.570 |
FLT1 | UBC | ENSP00000282397 | ENSP00000344818 | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | ubiquitin C | 0.650 |
HECW2 | UBC | ENSP00000260983 | ENSP00000344818 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2; E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 | ubiquitin C | 0.839 |
SERPINB12 | FLT1 | ENSP00000269491 | ENSP00000282397 | serpin peptidase inhibitor, clade B (ovalbumin), member 12; Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 0.570 |
SERPINB12 | SERPINF2 | ENSP00000269491 | ENSP00000321853 | serpin peptidase inhibitor, clade B (ovalbumin), member 12; Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin | 0.639 |
SERPINF2 | SERPINB12 | ENSP00000321853 | ENSP00000269491 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin | serpin peptidase inhibitor, clade B (ovalbumin), member 12; Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator | 0.639 |
SERPINF2 | UBC | ENSP00000321853 | ENSP00000344818 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin | ubiquitin C | 0.594 |
TBX21 | UBC | ENSP00000177694 | ENSP00000344818 | T-box 21; Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs | ubiquitin C | 0.624 |
UBC | AP2M1 | ENSP00000344818 | ENSP00000292807 | ubiquitin C | adaptor-related protein complex 2, mu 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a [...] | 0.979 |
UBC | BMI1 | ENSP00000344818 | ENSP00000365851 | ubiquitin C | BMI1 polycomb ring finger oncogene; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ’Lys-119’, rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 | 0.979 |