node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COMT | DBH | ENSP00000354511 | ENSP00000376776 | catechol-O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol | dopamine beta-hydroxylase (dopamine beta-monooxygenase); Conversion of dopamine to noradrenaline | 0.963 |
COMT | MAOA | ENSP00000354511 | ENSP00000340684 | catechol-O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol | monoamine oxidase A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine | 0.981 |
COMT | MAOB | ENSP00000354511 | ENSP00000367309 | catechol-O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol | monoamine oxidase B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine | 0.980 |
COMT | PNMT | ENSP00000354511 | ENSP00000269582 | catechol-O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol | phenylethanolamine N-methyltransferase; Converts noradrenaline to adrenaline | 0.963 |
DBH | COMT | ENSP00000376776 | ENSP00000354511 | dopamine beta-hydroxylase (dopamine beta-monooxygenase); Conversion of dopamine to noradrenaline | catechol-O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol | 0.963 |
DBH | MAOA | ENSP00000376776 | ENSP00000340684 | dopamine beta-hydroxylase (dopamine beta-monooxygenase); Conversion of dopamine to noradrenaline | monoamine oxidase A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine | 0.948 |
DBH | MAOB | ENSP00000376776 | ENSP00000367309 | dopamine beta-hydroxylase (dopamine beta-monooxygenase); Conversion of dopamine to noradrenaline | monoamine oxidase B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine | 0.939 |
DBH | PNMT | ENSP00000376776 | ENSP00000269582 | dopamine beta-hydroxylase (dopamine beta-monooxygenase); Conversion of dopamine to noradrenaline | phenylethanolamine N-methyltransferase; Converts noradrenaline to adrenaline | 0.986 |
MAOA | COMT | ENSP00000340684 | ENSP00000354511 | monoamine oxidase A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine | catechol-O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol | 0.981 |
MAOA | DBH | ENSP00000340684 | ENSP00000376776 | monoamine oxidase A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine | dopamine beta-hydroxylase (dopamine beta-monooxygenase); Conversion of dopamine to noradrenaline | 0.948 |
MAOA | PNMT | ENSP00000340684 | ENSP00000269582 | monoamine oxidase A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine | phenylethanolamine N-methyltransferase; Converts noradrenaline to adrenaline | 0.938 |
MAOB | COMT | ENSP00000367309 | ENSP00000354511 | monoamine oxidase B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine | catechol-O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol | 0.980 |
MAOB | DBH | ENSP00000367309 | ENSP00000376776 | monoamine oxidase B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine | dopamine beta-hydroxylase (dopamine beta-monooxygenase); Conversion of dopamine to noradrenaline | 0.939 |
MAOB | PNMT | ENSP00000367309 | ENSP00000269582 | monoamine oxidase B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine | phenylethanolamine N-methyltransferase; Converts noradrenaline to adrenaline | 0.929 |
PNMT | COMT | ENSP00000269582 | ENSP00000354511 | phenylethanolamine N-methyltransferase; Converts noradrenaline to adrenaline | catechol-O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol | 0.963 |
PNMT | DBH | ENSP00000269582 | ENSP00000376776 | phenylethanolamine N-methyltransferase; Converts noradrenaline to adrenaline | dopamine beta-hydroxylase (dopamine beta-monooxygenase); Conversion of dopamine to noradrenaline | 0.986 |
PNMT | MAOA | ENSP00000269582 | ENSP00000340684 | phenylethanolamine N-methyltransferase; Converts noradrenaline to adrenaline | monoamine oxidase A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine | 0.938 |
PNMT | MAOB | ENSP00000269582 | ENSP00000367309 | phenylethanolamine N-methyltransferase; Converts noradrenaline to adrenaline | monoamine oxidase B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine | 0.929 |
TERF1 | TERF2IP | ENSP00000276603 | ENSP00000300086 | telomeric repeat binding factor (NIMA-interacting) 1; Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double- stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair [...] | telomeric repeat binding factor 2, interacting protein; Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR [...] | 0.989 |
TERF2IP | TERF1 | ENSP00000300086 | ENSP00000276603 | telomeric repeat binding factor 2, interacting protein; Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR [...] | telomeric repeat binding factor (NIMA-interacting) 1; Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double- stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair [...] | 0.989 |