26 items (Homo sapiens) - STRING network view

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	C5	complement component 5; Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled (1676 aa)
	GCLC	glutamate-cysteine ligase, catalytic subunit (637 aa)
	C3	complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates (1663 aa)
	GGT1	gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive (569 aa)
	KLB	klotho beta; Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity) (1044 aa)
	LCT	lactase; LPH splits lactose in the small intestine (1927 aa)
	RNPEPL1	arginyl aminopeptidase (aminopeptidase B)-like 1 (494 aa)
	GGTLC1	gamma-glutamyltransferase light chain 1 (225 aa)
	A2ML1	alpha-2-macroglobulin-like 1; Is able to inhibit all four classes of proteinases by a unique ’trapping’ mechanism. This protein has a peptide stretch, called the ’bait region’ which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates [...] (1454 aa)
	GGT7	gamma-glutamyltransferase 7; Cleaves glutathione conjugates (By similarity) (662 aa)
	RIMKLB	ribosomal modification protein rimK-like family member B; Catalyzes the synthesis of beta-citryl-glutamate and N- acetyl-aspartyl-glutamate. Beta-citryl-glutamate is synthesized more efficiently than N-acetyl-aspartyl-glutamate (By similarity) (386 aa)
	ME3	malic enzyme 3, NADP(+)-dependent, mitochondrial (604 aa)
	GCLM	glutamate-cysteine ligase, modifier subunit (274 aa)
	KL	klotho; May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity) (1012 aa)
	DENND4C	DENN/MADD domain containing 4C (1673 aa)
	GGT5	gamma-glutamyltransferase 5; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4) (587 aa)
	GGT2	gamma-glutamyltransferase 2; Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors (By similarity) (569 aa)
	DENND4A	DENN/MADD domain containing 4A; Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. According to PubMed-8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter (1906 aa)
	C4A	complement component 4A (Rodgers blood group) (1744 aa)
	RIMKLA	ribosomal modification protein rimK-like family member A; Catalyzes the synthesis of N-acetylaspartyl-glutamate (NAAG) (391 aa)
	GGTLC3	gamma-glutamyltransferase light chain 3 (236 aa)
	C4B	complement component 4B (Chido blood group) (1744 aa)
	GGTLC2	gamma-glutamyltransferase light chain 2 (218 aa)
	GGT6	gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) (493 aa)
	KLRP	glucosidase, beta, acid 3 (cytosolic) (EC-3.2.1.21) (162 aa)
	GBA3	Cytosolic beta-glucosidase ; Glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. Able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. Possesses beta- glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide (469 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C3	C4A	ENSP00000245907	ENSP00000396688	complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates	complement component 4A (Rodgers blood group)	0.919
C3	C4B	ENSP00000245907	ENSP00000415941	complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates	complement component 4B (Chido blood group)	0.849
C3	C5	ENSP00000245907	ENSP00000223642	complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates	complement component 5; Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled	0.960
C4A	C3	ENSP00000396688	ENSP00000245907	complement component 4A (Rodgers blood group)	complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates	0.919
C4B	C3	ENSP00000415941	ENSP00000245907	complement component 4B (Chido blood group)	complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates	0.849
C5	C3	ENSP00000223642	ENSP00000245907	complement component 5; Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled	complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates	0.960
GCLC	GCLM	ENSP00000229416	ENSP00000359258	glutamate-cysteine ligase, catalytic subunit	glutamate-cysteine ligase, modifier subunit	0.999
GCLC	GGT1	ENSP00000229416	ENSP00000248923	glutamate-cysteine ligase, catalytic subunit	gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive	0.954
GCLC	GGT5	ENSP00000229416	ENSP00000381340	glutamate-cysteine ligase, catalytic subunit	gamma-glutamyltransferase 5; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4)	0.921
GCLC	GGT6	ENSP00000229416	ENSP00000458307	glutamate-cysteine ligase, catalytic subunit	gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity)	0.926
GCLC	GGT7	ENSP00000229416	ENSP00000338964	glutamate-cysteine ligase, catalytic subunit	gamma-glutamyltransferase 7; Cleaves glutathione conjugates (By similarity)	0.924
GCLM	GCLC	ENSP00000359258	ENSP00000229416	glutamate-cysteine ligase, modifier subunit	glutamate-cysteine ligase, catalytic subunit	0.999
GCLM	GGT1	ENSP00000359258	ENSP00000248923	glutamate-cysteine ligase, modifier subunit	gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive	0.927
GCLM	GGT5	ENSP00000359258	ENSP00000381340	glutamate-cysteine ligase, modifier subunit	gamma-glutamyltransferase 5; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4)	0.913
GCLM	GGT6	ENSP00000359258	ENSP00000458307	glutamate-cysteine ligase, modifier subunit	gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity)	0.900
GCLM	GGT7	ENSP00000359258	ENSP00000338964	glutamate-cysteine ligase, modifier subunit	gamma-glutamyltransferase 7; Cleaves glutathione conjugates (By similarity)	0.900
GGT1	GCLC	ENSP00000248923	ENSP00000229416	gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive	glutamate-cysteine ligase, catalytic subunit	0.954
GGT1	GCLM	ENSP00000248923	ENSP00000359258	gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive	glutamate-cysteine ligase, modifier subunit	0.927
GGT5	GCLC	ENSP00000381340	ENSP00000229416	gamma-glutamyltransferase 5; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4)	glutamate-cysteine ligase, catalytic subunit	0.921
GGT5	GCLM	ENSP00000381340	ENSP00000359258	gamma-glutamyltransferase 5; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4)	glutamate-cysteine ligase, modifier subunit	0.913

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