node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHCYL1 | SH3BGRL3 | ENSP00000358814 | ENSP00000270792 | adenosylhomocysteinase-like 1 | SH3 domain binding glutamic acid-rich protein like 3; Could act as a modulator of glutaredoxin biological activity | 0.644 |
AHCYL1 | UBC | ENSP00000358814 | ENSP00000344818 | adenosylhomocysteinase-like 1 | ubiquitin C | 0.902 |
ANXA5 | UBC | ENSP00000296511 | ENSP00000344818 | annexin A5; This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade | ubiquitin C | 0.968 |
EGFR | TPT1 | ENSP00000275493 | ENSP00000431872 | epidermal growth factor receptor | tumor protein, translationally-controlled 1; Involved in calcium binding and microtubule stabilization | 0.575 |
EGFR | UBC | ENSP00000275493 | ENSP00000344818 | epidermal growth factor receptor | ubiquitin C | 0.999 |
EGFR | YWHAQ | ENSP00000275493 | ENSP00000238081 | epidermal growth factor receptor | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 | 0.792 |
FKBP8 | TPT1 | ENSP00000222308 | ENSP00000431872 | FK506 binding protein 8, 38kDa; Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis | tumor protein, translationally-controlled 1; Involved in calcium binding and microtubule stabilization | 0.579 |
FKBP8 | UBC | ENSP00000222308 | ENSP00000344818 | FK506 binding protein 8, 38kDa; Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis | ubiquitin C | 0.917 |
PIP5K1A | SH3BGRL3 | ENSP00000357883 | ENSP00000270792 | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organ [...] | SH3 domain binding glutamic acid-rich protein like 3; Could act as a modulator of glutaredoxin biological activity | 0.644 |
PIP5K1A | UBC | ENSP00000357883 | ENSP00000344818 | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organ [...] | ubiquitin C | 0.984 |
SH3BGRL3 | AHCYL1 | ENSP00000270792 | ENSP00000358814 | SH3 domain binding glutamic acid-rich protein like 3; Could act as a modulator of glutaredoxin biological activity | adenosylhomocysteinase-like 1 | 0.644 |
SH3BGRL3 | PIP5K1A | ENSP00000270792 | ENSP00000357883 | SH3 domain binding glutamic acid-rich protein like 3; Could act as a modulator of glutaredoxin biological activity | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organ [...] | 0.644 |
SH3BGRL3 | STXBP3 | ENSP00000270792 | ENSP00000359025 | SH3 domain binding glutamic acid-rich protein like 3; Could act as a modulator of glutaredoxin biological activity | syntaxin binding protein 3; Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity) | 0.644 |
SH3BGRL3 | UBC | ENSP00000270792 | ENSP00000344818 | SH3 domain binding glutamic acid-rich protein like 3; Could act as a modulator of glutaredoxin biological activity | ubiquitin C | 0.721 |
SH3BGRL3 | USP3 | ENSP00000270792 | ENSP00000369681 | SH3 domain binding glutamic acid-rich protein like 3; Could act as a modulator of glutaredoxin biological activity | ubiquitin specific peptidase 3; Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin | 0.644 |
STXBP3 | SH3BGRL3 | ENSP00000359025 | ENSP00000270792 | syntaxin binding protein 3; Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity) | SH3 domain binding glutamic acid-rich protein like 3; Could act as a modulator of glutaredoxin biological activity | 0.644 |
STXBP3 | UBC | ENSP00000359025 | ENSP00000344818 | syntaxin binding protein 3; Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity) | ubiquitin C | 0.865 |
TPT1 | EGFR | ENSP00000431872 | ENSP00000275493 | tumor protein, translationally-controlled 1; Involved in calcium binding and microtubule stabilization | epidermal growth factor receptor | 0.575 |
TPT1 | FKBP8 | ENSP00000431872 | ENSP00000222308 | tumor protein, translationally-controlled 1; Involved in calcium binding and microtubule stabilization | FK506 binding protein 8, 38kDa; Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis | 0.579 |
TPT1 | UBC | ENSP00000431872 | ENSP00000344818 | tumor protein, translationally-controlled 1; Involved in calcium binding and microtubule stabilization | ubiquitin C | 0.964 |