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GOLT1A GOLT1A ENSG00000261576 ENSG00000261576 COG8 COG8 ARL1 ARL1 SFT2D2 SFT2D2 COG6 COG6 KIAA1432 KIAA1432 RAB34 RAB34 UBC UBC GOLT1B GOLT1B RAB6A RAB6A RAB36 RAB36 RAB6B RAB6B STX5 STX5 ARL16 ARL16 STX16 STX16 RAB41 RAB41 VTI1A VTI1A ENSG00000254995 ENSG00000254995 RAB6C RAB6C YKT6 YKT6 VTI1B VTI1B ENSG00000260371 ENSG00000260371 SEC22C SEC22C SEC22A SEC22A VPS39 VPS39
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
YKT6YKT6 v-SNARE homolog (S. cerevisiae); Vesicular soluble NSF attachment protein receptor (v- SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity (198 aa)
GOLT1Bgolgi transport 1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex (138 aa)
ARL1ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (181 aa)
RAB36RAB36, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) (333 aa)
SEC22CSEC22 vesicle trafficking protein homolog C (S. cerevisiae); May be involved in vesicle transport between the ER and the Golgi complex (303 aa)
SFT2D2SFT2 domain containing 2; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex (By similarity) (160 aa)
RAB41RAB41, member RAS oncogene family (221 aa)
RAB6BRAB6B, member RAS oncogene family; Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (208 aa)
STX5syntaxin 5; Mediates endoplasmic reticulum to Golgi transport (By similarity) (355 aa)
COG8component of oligomeric golgi complex 8; Required for normal Golgi function (By similarity) (612 aa)
GOLT1Agolgi transport 1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex (132 aa)
SEC22ASEC22 vesicle trafficking protein homolog A (S. cerevisiae); May be involved in vesicle transport between the ER and the Golgi complex (By similarity) (307 aa)
RAB6ARAB6A, member RAS oncogene family; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity (208 aa)
VPS39vacuolar protein sorting 39 homolog (S. cerevisiae); May play a role in clustering and fusion of late endosomes and lysosomes. Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation (875 aa)
UBCubiquitin C (685 aa)
STX16syntaxin 16 (325 aa)
VTI1Avesicle transport through interaction with t-SNAREs homolog 1A (yeast); V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with [...] (217 aa)
ARL16ADP-ribosylation factor-like 16 (197 aa)
RAB6CRAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression (254 aa)
COG6component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) (657 aa)
RAB34RAB34, member RAS oncogene family; Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes (316 aa)
KIAA1432KIAA1432 (1423 aa)
VTI1Bvesicle transport through interaction with t-SNAREs homolog 1B (yeast); V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence (232 aa)
ENSG00000260371Uncharacterized protein (156 aa)
ENSG00000254995STX16-NPEPL1 readthrough (non-protein coding) (382 aa)
ENSG00000261576Uncharacterized protein (164 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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