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ADAMTS13 ADAMTS13 ADAMTS14 ADAMTS14 ADAMTS6 ADAMTS6 ADAMTS10 ADAMTS10 THSD7B THSD7B POFUT2 POFUT2 ADAMTSL1 ADAMTSL1 SEMA5A SEMA5A CFP CFP ADAMTSL3 ADAMTSL3 ADAMTS20 ADAMTS20 ADAMTSL4 ADAMTSL4 ADAMTS17 ADAMTS17 B3GALTL B3GALTL THSD7A THSD7A THBS1 THBS1 ADAMTS8 ADAMTS8 ADAMTS15 ADAMTS15 SPON2 SPON2 ADAMTS3 ADAMTS3 THSD4 THSD4 ADAMTS18 ADAMTS18 ADAMTS16 ADAMTS16 ADAMTS4 ADAMTS4 ADAMTS9 ADAMTS9 ADAMTS12 ADAMTS12
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
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protein homology
Your Input:
CFPcomplement factor properdin; A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes (469 aa)
ADAMTS8ADAM metallopeptidase with thrombospondin type 1 motif, 8; Has anti-angiogenic properties (889 aa)
THBS1thrombospondin 1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties (1170 aa)
THSD4thrombospondin, type I, domain containing 4; Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity) (1018 aa)
ADAMTS17ADAM metallopeptidase with thrombospondin type 1 motif, 17 (1095 aa)
ADAMTS10ADAM metallopeptidase with thrombospondin type 1 motif, 10; Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues (1103 aa)
ADAMTSL4ADAMTS-like 4; Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis (1074 aa)
THSD7Bthrombospondin, type I, domain containing 7B (1609 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif, 16 (1224 aa)
ADAMTS18ADAM metallopeptidase with thrombospondin type 1 motif, 18 (1221 aa)
ADAMTS3ADAM metallopeptidase with thrombospondin type 1 motif, 3; Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens (1205 aa)
ADAMTSL3ADAMTS-like 3 (1691 aa)
SPON2spondin 2, extracellular matrix protein; Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern- recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS) (331 aa)
ADAMTS15ADAM metallopeptidase with thrombospondin type 1 motif, 15 (950 aa)
POFUT2protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization [...] (429 aa)
B3GALTLbeta 1,3-galactosyltransferase-like; O-fucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan (498 aa)
ADAMTS4ADAM metallopeptidase with thrombospondin type 1 motif, 4; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the ’392-Glu-|-Ala-393’ site (837 aa)
ADAMTS13ADAM metallopeptidase with thrombospondin type 1 motif, 13; Cleaves the vWF multimers in plasma into smaller forms (1427 aa)
ADAMTS14ADAM metallopeptidase with thrombospondin type 1 motif, 14; Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity (1226 aa)
ADAMTSL1ADAMTS-like 1 (1762 aa)
ADAMTS6ADAM metallopeptidase with thrombospondin type 1 motif, 6 (1117 aa)
SEMA5Asema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A; Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collaps [...] (1074 aa)
ADAMTS20ADAM metallopeptidase with thrombospondin type 1 motif, 20; May play a role in tissue-remodeling process occurring in both normal and pathological conditions (1910 aa)
THSD7Athrombospondin, type I, domain containing 7A; The soluble form promotes endothelial cell migration and filopodia formationduring angiogenesis via a FAK-dependent mechanism (1657 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif, 9; Cleaves the large aggregating proteoglycans, aggrecan and versican (1935 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif, 12; Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties (1594 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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