13 items (Homo sapiens) - STRING network view

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Your Input:
	APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5’ [...] (318 aa)
	FBL	fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (321 aa)
	RPS4Y1	ribosomal protein S4, Y-linked 1 (263 aa)
	HEXB	hexosaminidase B (beta polypeptide); Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues (556 aa)
	EIF2D	eukaryotic translation initiation factor 2D (584 aa)
	RPS4Y2	ribosomal protein S4, Y-linked 2 (263 aa)
	ACHE	acetylcholinesterase (617 aa)
	DDX3Y	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked; Probable ATP-dependent RNA helicase. May play a role in spermatogenesis (660 aa)
	RPS4X	ribosomal protein S4, X-linked (263 aa)
	APEX2	APEX nuclease (apurinic/apyrimidinic endonuclease) 2; Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5’-deoxyribose phosphate and 3’-hydroxyl ends. Displays also double-stranded DNA 3’-5’ exonuclease, 3’-phosphodiesterase activities. Shows robust 3’-5’ exonuclease activity on 3’-recessed he [...] (518 aa)
	DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double stranded DNA with a preference for 5’- single stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can [...] (662 aa)
	RPS4XP21	ribosomal protein S4X pseudogene 21 (273 aa)
	DDX4	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; May play a role in germ cell development. May play a role in sperm motility (724 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACHE	EIF2D	ENSP00000303211	ENSP00000271764	acetylcholinesterase	eukaryotic translation initiation factor 2D	0.576
DDX3X	RPS4X	ENSP00000382840	ENSP00000362744	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double stranded DNA with a preference for 5’- single stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can [...]	ribosomal protein S4, X-linked	0.488
DDX3X	RPS4Y1	ENSP00000382840	ENSP00000250784	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double stranded DNA with a preference for 5’- single stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can [...]	ribosomal protein S4, Y-linked 1	0.509
DDX3X	RPS4Y2	ENSP00000382840	ENSP00000288666	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double stranded DNA with a preference for 5’- single stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can [...]	ribosomal protein S4, Y-linked 2	0.418
DDX3Y	RPS4X	ENSP00000336725	ENSP00000362744	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked; Probable ATP-dependent RNA helicase. May play a role in spermatogenesis	ribosomal protein S4, X-linked	0.499
DDX3Y	RPS4Y1	ENSP00000336725	ENSP00000250784	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked; Probable ATP-dependent RNA helicase. May play a role in spermatogenesis	ribosomal protein S4, Y-linked 1	0.739
DDX3Y	RPS4Y2	ENSP00000336725	ENSP00000288666	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked; Probable ATP-dependent RNA helicase. May play a role in spermatogenesis	ribosomal protein S4, Y-linked 2	0.555
EIF2D	ACHE	ENSP00000271764	ENSP00000303211	eukaryotic translation initiation factor 2D	acetylcholinesterase	0.576
EIF2D	HEXB	ENSP00000271764	ENSP00000261416	eukaryotic translation initiation factor 2D	hexosaminidase B (beta polypeptide); Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues	0.576
FBL	RPS4X	ENSP00000221801	ENSP00000362744	fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	ribosomal protein S4, X-linked	0.882
FBL	RPS4XP21	ENSP00000221801	ENSP00000420227	fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	ribosomal protein S4X pseudogene 21	0.670
FBL	RPS4Y1	ENSP00000221801	ENSP00000250784	fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	ribosomal protein S4, Y-linked 1	0.688
FBL	RPS4Y2	ENSP00000221801	ENSP00000288666	fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	ribosomal protein S4, Y-linked 2	0.691
HEXB	EIF2D	ENSP00000261416	ENSP00000271764	hexosaminidase B (beta polypeptide); Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues	eukaryotic translation initiation factor 2D	0.576
RPS4X	DDX3X	ENSP00000362744	ENSP00000382840	ribosomal protein S4, X-linked	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double stranded DNA with a preference for 5’- single stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can [...]	0.488
RPS4X	DDX3Y	ENSP00000362744	ENSP00000336725	ribosomal protein S4, X-linked	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked; Probable ATP-dependent RNA helicase. May play a role in spermatogenesis	0.499
RPS4X	FBL	ENSP00000362744	ENSP00000221801	ribosomal protein S4, X-linked	fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	0.882
RPS4X	RPS4Y1	ENSP00000362744	ENSP00000250784	ribosomal protein S4, X-linked	ribosomal protein S4, Y-linked 1	0.901
RPS4XP21	FBL	ENSP00000420227	ENSP00000221801	ribosomal protein S4X pseudogene 21	fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	0.670
RPS4Y1	DDX3X	ENSP00000250784	ENSP00000382840	ribosomal protein S4, Y-linked 1	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double stranded DNA with a preference for 5’- single stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can [...]	0.509

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