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PLCG1 | phospholipase C, gamma 1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (1291 aa) | |||
PTPRE | protein tyrosine phosphatase, receptor type, E; Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity) (700 aa) | |||
KIF13A | kinesin family member 13A (1805 aa) | |||
KIF1B | kinesin family member 1B (1770 aa) | |||
PTPRQ | protein tyrosine phosphatase, receptor type, Q; Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in viv [...] (2295 aa) | |||
PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (By similarity) (701 aa) | |||
ERC2 | ELKS/RAB6-interacting/CAST family member 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ (957 aa) | |||
STARD9 | StAR-related lipid transfer (START) domain containing 9; Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM) (4700 aa) | |||
KIF1C | kinesin family member 1C; Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end- directed motility (1103 aa) | |||
KIF1A | kinesin family member 1A (1690 aa) | |||
PTPRU | protein tyrosine phosphatase, receptor type, U (1446 aa) | |||
UBC | ubiquitin C (685 aa) | |||
PTPRD | protein tyrosine phosphatase, receptor type, D (1912 aa) | |||
PTPRS | protein tyrosine phosphatase, receptor type, S; Interacts with LAR-interacting protein LIP.1 (1948 aa) | |||
PTPRF | protein tyrosine phosphatase, receptor type, F; Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) (1907 aa) | |||
KIF14 | kinesin family member 14; Plays an essential role in cytokinesis (1648 aa) | |||
PTPRC | protein tyrosine phosphatase, receptor type, C; Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity) (1304 aa) | |||
AGTPBP1 | ATP/GTP binding protein 1 (1186 aa) | |||
PTPRA | protein tyrosine phosphatase, receptor type, A (802 aa) | |||
PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1; May be involved in the regulation of specific developmental processes in the CNS (2315 aa) | |||
GIT1 | G protein-coupled receptor kinase interacting ArfGAP 1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes (770 aa) | |||
CAST | calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue (750 aa) | |||
KIF16B | kinesin family member 16B (1392 aa) | |||
NCOA2 | nuclear receptor coactivator 2; Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues (1464 aa) | |||
PTPRG | protein tyrosine phosphatase, receptor type, G; Possesses tyrosine phosphatase activity (1445 aa) | |||
KIF13B | kinesin family member 13B; Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes (1826 aa) |