Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
KIF13B KIF13B KIF16B KIF16B KIF13A KIF13A KIF1A KIF1A KIF1C KIF1C PTPRZ1 PTPRZ1 PTPRU PTPRU PLCG1 PLCG1 GIT1 GIT1 ERC2 ERC2 PTPRC PTPRC AGTPBP1 AGTPBP1 PTPRG PTPRG UBC UBC CAST CAST PTPRF PTPRF PPFIA4 PPFIA4 PTPRQ PTPRQ KIF1B KIF1B NCOA2 NCOA2 STARD9 STARD9 KIF14 KIF14 PTPRS PTPRS PTPRE PTPRE PTPRA PTPRA PTPRD PTPRD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
PLCG1phospholipase C, gamma 1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (1291 aa)
PTPREprotein tyrosine phosphatase, receptor type, E; Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity) (700 aa)
KIF13Akinesin family member 13A (1805 aa)
KIF1Bkinesin family member 1B (1770 aa)
PTPRQprotein tyrosine phosphatase, receptor type, Q; Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in viv [...] (2295 aa)
PPFIA4protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (By similarity) (701 aa)
ERC2ELKS/RAB6-interacting/CAST family member 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ (957 aa)
STARD9StAR-related lipid transfer (START) domain containing 9; Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM) (4700 aa)
KIF1Ckinesin family member 1C; Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end- directed motility (1103 aa)
KIF1Akinesin family member 1A (1690 aa)
PTPRUprotein tyrosine phosphatase, receptor type, U (1446 aa)
UBCubiquitin C (685 aa)
PTPRDprotein tyrosine phosphatase, receptor type, D (1912 aa)
PTPRSprotein tyrosine phosphatase, receptor type, S; Interacts with LAR-interacting protein LIP.1 (1948 aa)
PTPRFprotein tyrosine phosphatase, receptor type, F; Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) (1907 aa)
KIF14kinesin family member 14; Plays an essential role in cytokinesis (1648 aa)
PTPRCprotein tyrosine phosphatase, receptor type, C; Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity) (1304 aa)
AGTPBP1ATP/GTP binding protein 1 (1186 aa)
PTPRAprotein tyrosine phosphatase, receptor type, A (802 aa)
PTPRZ1protein tyrosine phosphatase, receptor-type, Z polypeptide 1; May be involved in the regulation of specific developmental processes in the CNS (2315 aa)
GIT1G protein-coupled receptor kinase interacting ArfGAP 1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes (770 aa)
CASTcalpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue (750 aa)
KIF16Bkinesin family member 16B (1392 aa)
NCOA2nuclear receptor coactivator 2; Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues (1464 aa)
PTPRGprotein tyrosine phosphatase, receptor type, G; Possesses tyrosine phosphatase activity (1445 aa)
KIF13Bkinesin family member 13B; Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes (1826 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (27%)