node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGTPBP1 | UBC | ENSP00000365251 | ENSP00000344818 | ATP/GTP binding protein 1 | ubiquitin C | 0.504 |
CAST | PPFIA4 | ENSP00000379157 | ENSP00000272198 | calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (By similarity) | 0.575 |
CAST | UBC | ENSP00000379157 | ENSP00000344818 | calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue | ubiquitin C | 0.483 |
ERC2 | GIT1 | ENSP00000288221 | ENSP00000378338 | ELKS/RAB6-interacting/CAST family member 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ | G protein-coupled receptor kinase interacting ArfGAP 1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes | 0.575 |
ERC2 | PPFIA4 | ENSP00000288221 | ENSP00000272198 | ELKS/RAB6-interacting/CAST family member 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (By similarity) | 0.619 |
GIT1 | ERC2 | ENSP00000378338 | ENSP00000288221 | G protein-coupled receptor kinase interacting ArfGAP 1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes | ELKS/RAB6-interacting/CAST family member 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ | 0.575 |
GIT1 | KIF1A | ENSP00000378338 | ENSP00000322791 | G protein-coupled receptor kinase interacting ArfGAP 1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes | kinesin family member 1A | 0.598 |
GIT1 | PLCG1 | ENSP00000378338 | ENSP00000244007 | G protein-coupled receptor kinase interacting ArfGAP 1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes | phospholipase C, gamma 1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration | 0.959 |
GIT1 | PPFIA4 | ENSP00000378338 | ENSP00000272198 | G protein-coupled receptor kinase interacting ArfGAP 1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (By similarity) | 0.808 |
GIT1 | PTPRF | ENSP00000378338 | ENSP00000353030 | G protein-coupled receptor kinase interacting ArfGAP 1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes | protein tyrosine phosphatase, receptor type, F; Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) | 0.574 |
GIT1 | PTPRZ1 | ENSP00000378338 | ENSP00000377047 | G protein-coupled receptor kinase interacting ArfGAP 1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes | protein tyrosine phosphatase, receptor-type, Z polypeptide 1; May be involved in the regulation of specific developmental processes in the CNS | 0.752 |
GIT1 | UBC | ENSP00000378338 | ENSP00000344818 | G protein-coupled receptor kinase interacting ArfGAP 1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes | ubiquitin C | 0.621 |
KIF14 | UBC | ENSP00000356319 | ENSP00000344818 | kinesin family member 14; Plays an essential role in cytokinesis | ubiquitin C | 0.830 |
KIF16B | UBC | ENSP00000384164 | ENSP00000344818 | kinesin family member 16B | ubiquitin C | 0.415 |
KIF1A | GIT1 | ENSP00000322791 | ENSP00000378338 | kinesin family member 1A | G protein-coupled receptor kinase interacting ArfGAP 1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes | 0.598 |
KIF1A | UBC | ENSP00000322791 | ENSP00000344818 | kinesin family member 1A | ubiquitin C | 0.759 |
KIF1B | STARD9 | ENSP00000263934 | ENSP00000290607 | kinesin family member 1B | StAR-related lipid transfer (START) domain containing 9; Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM) | 0.600 |
KIF1B | UBC | ENSP00000263934 | ENSP00000344818 | kinesin family member 1B | ubiquitin C | 0.905 |
KIF1C | UBC | ENSP00000320821 | ENSP00000344818 | kinesin family member 1C; Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end- directed motility | ubiquitin C | 0.544 |
NCOA2 | PPFIA4 | ENSP00000399968 | ENSP00000272198 | nuclear receptor coactivator 2; Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (By similarity) | 0.576 |