Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | RPS12 | ribosomal protein S12 (132 aa) | ||
 | RPS16 | ribosomal protein S16 (146 aa) | ||
 | AP2S1 | adaptor-related protein complex 2, sigma 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as [...] (142 aa) | ||
 | RPS11 | ribosomal protein S11 (158 aa) | ||
 | RPS27A | ribosomal protein S27a (156 aa) | ||
 | RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity) (491 aa) | ||
 | RPS7 | ribosomal protein S7; Required for rRNA maturation (194 aa) | ||
 | ZFAND4 | zinc finger, AN1-type domain 4 (727 aa) | ||
 | NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (1247 aa) | ||
 | RPS17 | ribosomal protein S17 (135 aa) | ||
 | RPS17L | ribosomal protein S17-like (135 aa) | ||
 | RPS3A | ribosomal protein S3A; May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity) (264 aa) | ||
 | RPSA | ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. A [...] (295 aa) | ||
 | RPS10 | ribosomal protein S10; Component of the 40S ribosomal subunit (165 aa) | ||
 | RPS26 | ribosomal protein S26 (115 aa) | ||
 | RPS6 | ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (249 aa) | ||
 | POLD2 | polymerase (DNA directed), delta 2, accessory subunit; The function of the small subunit is not yet clear (469 aa) | ||
 | UBA52 | ubiquitin A-52 residue ribosomal protein fusion product 1 (128 aa) | ||
 | KCTD7 | potassium channel tetramerisation domain containing 7; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity) (491 aa) | ||
 | RPS24 | ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits (289 aa) | ||
 | FAU | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (133 aa) | ||
 | RPS25 | ribosomal protein S25 (125 aa) | ||
 | ENSG00000260836 | Uncharacterized protein (293 aa) | ||
 | RPS15 | ribosomal protein S15 (145 aa) | ||
 | RPS19 | ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits (145 aa) | ||
 | RPS28 | ribosomal protein S28 (69 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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