node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADCY3 | CALM1 | ENSP00000260600 | ENSP00000349467 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | calmodulin 1 (phosphorylase kinase, delta) | 0.813 |
ADCY3 | CALML3 | ENSP00000260600 | ENSP00000315299 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | calmodulin-like 3; May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates | 0.810 |
ADCY3 | CALML5 | ENSP00000260600 | ENSP00000369689 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | calmodulin-like 5; Binds calcium. May be involved in terminal differentiation of keratinocytes | 0.810 |
ADCY3 | CALML6 | ENSP00000260600 | ENSP00000304643 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | calmodulin-like 6 | 0.810 |
ADCY3 | CNGA3 | ENSP00000260600 | ENSP00000272602 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | cyclic nucleotide gated channel alpha 3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked elec [...] | 0.822 |
ADCY3 | GNAT2 | ENSP00000260600 | ENSP00000251337 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase | 0.408 |
ADCY3 | PDE6C | ENSP00000260600 | ENSP00000360502 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | phosphodiesterase 6C, cGMP-specific, cone, alpha prime | 0.962 |
ADCY3 | PDE6H | ENSP00000260600 | ENSP00000266395 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | phosphodiesterase 6H, cGMP-specific, cone, gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones | 0.900 |
CALM1 | ADCY3 | ENSP00000349467 | ENSP00000260600 | calmodulin 1 (phosphorylase kinase, delta) | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | 0.813 |
CALM1 | CNGA3 | ENSP00000349467 | ENSP00000272602 | calmodulin 1 (phosphorylase kinase, delta) | cyclic nucleotide gated channel alpha 3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked elec [...] | 0.800 |
CALML3 | ADCY3 | ENSP00000315299 | ENSP00000260600 | calmodulin-like 3; May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | 0.810 |
CALML3 | CNGA3 | ENSP00000315299 | ENSP00000272602 | calmodulin-like 3; May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates | cyclic nucleotide gated channel alpha 3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked elec [...] | 0.800 |
CALML5 | ADCY3 | ENSP00000369689 | ENSP00000260600 | calmodulin-like 5; Binds calcium. May be involved in terminal differentiation of keratinocytes | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | 0.810 |
CALML5 | CNGA3 | ENSP00000369689 | ENSP00000272602 | calmodulin-like 5; Binds calcium. May be involved in terminal differentiation of keratinocytes | cyclic nucleotide gated channel alpha 3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked elec [...] | 0.800 |
CALML6 | ADCY3 | ENSP00000304643 | ENSP00000260600 | calmodulin-like 6 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | 0.810 |
CALML6 | CNGA3 | ENSP00000304643 | ENSP00000272602 | calmodulin-like 6 | cyclic nucleotide gated channel alpha 3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked elec [...] | 0.800 |
CLCA1 | CNGA3 | ENSP00000234701 | ENSP00000272602 | chloride channel accessory 1; May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC | cyclic nucleotide gated channel alpha 3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked elec [...] | 0.800 |
CLCA2 | CNGA3 | ENSP00000359596 | ENSP00000272602 | chloride channel accessory 2; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4 | cyclic nucleotide gated channel alpha 3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked elec [...] | 0.800 |
CLCA4 | CNGA3 | ENSP00000359594 | ENSP00000272602 | chloride channel accessory 4; May be involved in mediating calcium-activated chloride conductance | cyclic nucleotide gated channel alpha 3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked elec [...] | 0.800 |
CNGA3 | ADCY3 | ENSP00000272602 | ENSP00000260600 | cyclic nucleotide gated channel alpha 3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked elec [...] | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | 0.822 |