Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | REEP6 | receptor accessory protein 6; May enhance the cell surface expression of odorant receptors (By similarity) (184 aa) | ||
 | RTN2 | reticulon 2 (545 aa) | ||
 | REEP2 | receptor accessory protein 2; May enhance the cell surface expression of odorant receptors (By similarity) (252 aa) | ||
 | RTN1 | reticulon 1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells (776 aa) | ||
 | KIAA1715 | KIAA1715; May be involved in limb and central nervous system development (By similarity) (428 aa) | ||
 | STK32B | serine/threonine kinase 32B (414 aa) | ||
 | STK32C | serine/threonine kinase 32C (486 aa) | ||
 | TMED3 | transmembrane emp24 protein transport domain containing 3; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network (217 aa) | ||
 | REEP4 | receptor accessory protein 4; May enhance the cell surface expression of odorant receptors (By similarity) (257 aa) | ||
 | RTN4 | reticulon 4 (1192 aa) | ||
 | RTN3 | reticulon 3 (1013 aa) | ||
 | REEP3 | receptor accessory protein 3; May enhance the cell surface expression of odorant receptors (By similarity) (255 aa) | ||
 | EDA | ectodysplasin A (391 aa) | ||
 | REEP5 | receptor accessory protein 5; May promote functional cell surface expression of olfactory receptors (189 aa) | ||
 | LLGL2 | lethal giant larvae homolog 2 (Drosophila); Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity (1020 aa) | ||
 | CHMP1A | charged multivesicular body protein 1A; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] (196 aa) | ||
 | STK32A | serine/threonine kinase 32A (396 aa) | ||
 | SYNPR | synaptoporin; Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity) (285 aa) | ||
 | TMEM33 | transmembrane protein 33 (247 aa) | ||
 | REEP1 | receptor accessory protein 1; Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors (208 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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