Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | CFTR | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (1480 aa) | ||
 | ABCC6 | ATP-binding cassette, sub-family C (CFTR/MRP), member 6; May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (1503 aa) | ||
 | ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 (655 aa) | ||
 | NR1H2 | nuclear receptor subfamily 1, group H, member 2; Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5’-AGGTCA-3’ and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity) (460 aa) | ||
 | ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9; Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (1549 aa) | ||
 | ABCB4 | ATP-binding cassette, sub-family B (MDR/TAP), member 4; Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte (1286 aa) | ||
 | ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (1280 aa) | ||
 | ABCA12 | ATP-binding cassette, sub-family A (ABC1), member 12; Probable transporter involved in lipid homeostasis (2595 aa) | ||
 | ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 (1527 aa) | ||
 | ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 (1437 aa) | ||
 | UBC | ubiquitin C (685 aa) | ||
 | TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) (808 aa) | ||
 | ABCC11 | ATP-binding cassette, sub-family C (CFTR/MRP), member 11; Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycochola [...] (1382 aa) | ||
 | ABCB8 | ATP-binding cassette, sub-family B (MDR/TAP), member 8 (718 aa) | ||
 | ABCB10 | ATP-binding cassette, sub-family B (MDR/TAP), member 10; May mediate critical mitochondrial transport functions related to heme biosynthesis (By similarity) (738 aa) | ||
 | ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter (1545 aa) | ||
 | ABCC10 | ATP-binding cassette, sub-family C (CFTR/MRP), member 10; ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion (1492 aa) | ||
 | PHF19 | PHD finger protein 19; Polycomb group (PcG) that specifically binds histone H3 trimethylated at ’Lys-36’ (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells- acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases NO66 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem ce [...] (580 aa) | ||
 | ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 (2261 aa) | ||
 | TAP2 | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) (653 aa) | ||
 | ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification (1325 aa) | ||
 | ABCC8 | ATP-binding cassette, sub-family C (CFTR/MRP), member 8; Putative subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release (1581 aa) | ||
 | ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (1531 aa) | ||
 | ABCB5 | ATP-binding cassette, sub-family B (MDR/TAP), member 5 (1257 aa) | ||
 | ENSG00000250264 | Uncharacterized protein (843 aa) | ||
 | RPS3 | ribosomal protein S3 (243 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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