node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABHD10 | ALAS1 | ENSP00000273359 | ENSP00000309259 | abhydrolase domain containing 10; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate | aminolevulinate, delta-, synthase 1 | 0.601 |
ABHD10 | ALAS2 | ENSP00000273359 | ENSP00000332369 | abhydrolase domain containing 10; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate | aminolevulinate, delta-, synthase 2 | 0.601 |
ABHD10 | GCAT | ENSP00000273359 | ENSP00000371110 | abhydrolase domain containing 10; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate | glycine C-acetyltransferase | 0.601 |
ABHD10 | SPTLC1 | ENSP00000273359 | ENSP00000262554 | abhydrolase domain containing 10; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate | serine palmitoyltransferase, long chain base subunit 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1- SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isoz [...] | 0.601 |
ABHD10 | SPTLC2 | ENSP00000273359 | ENSP00000216484 | abhydrolase domain containing 10; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate | serine palmitoyltransferase, long chain base subunit 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate | 0.601 |
ABHD10 | SPTLC3 | ENSP00000273359 | ENSP00000381968 | abhydrolase domain containing 10; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate | serine palmitoyltransferase, long chain base subunit 3; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, while the SPTLC1-SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference | 0.601 |
ABHD10 | UBC | ENSP00000273359 | ENSP00000344818 | abhydrolase domain containing 10; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate | ubiquitin C | 0.644 |
ALAS1 | ABHD10 | ENSP00000309259 | ENSP00000273359 | aminolevulinate, delta-, synthase 1 | abhydrolase domain containing 10; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate | 0.601 |
ALAS1 | ALAS2 | ENSP00000309259 | ENSP00000332369 | aminolevulinate, delta-, synthase 1 | aminolevulinate, delta-, synthase 2 | 0.807 |
ALAS1 | GCAT | ENSP00000309259 | ENSP00000371110 | aminolevulinate, delta-, synthase 1 | glycine C-acetyltransferase | 0.912 |
ALAS1 | UBC | ENSP00000309259 | ENSP00000344818 | aminolevulinate, delta-, synthase 1 | ubiquitin C | 0.820 |
ALAS2 | ABHD10 | ENSP00000332369 | ENSP00000273359 | aminolevulinate, delta-, synthase 2 | abhydrolase domain containing 10; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate | 0.601 |
ALAS2 | ALAS1 | ENSP00000332369 | ENSP00000309259 | aminolevulinate, delta-, synthase 2 | aminolevulinate, delta-, synthase 1 | 0.807 |
ALAS2 | GCAT | ENSP00000332369 | ENSP00000371110 | aminolevulinate, delta-, synthase 2 | glycine C-acetyltransferase | 0.909 |
EHMT1 | EHMT2 | ENSP00000417980 | ENSP00000364687 | euchromatic histone-lysine N-methyltransferase 1; Histone methyltransferase that specifically mono- and dimethylates ’Lys-9’ of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates ’Lys-27’ of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA [...] | euchromatic histone-lysine N-methyltransferase 2 | 0.436 |
EHMT1 | H2AFX | ENSP00000417980 | ENSP00000364310 | euchromatic histone-lysine N-methyltransferase 1; Histone methyltransferase that specifically mono- and dimethylates ’Lys-9’ of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates ’Lys-27’ of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA [...] | H2A histone family, member X; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in resp [...] | 0.411 |
EHMT1 | UBC | ENSP00000417980 | ENSP00000344818 | euchromatic histone-lysine N-methyltransferase 1; Histone methyltransferase that specifically mono- and dimethylates ’Lys-9’ of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates ’Lys-27’ of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA [...] | ubiquitin C | 0.991 |
EHMT2 | EHMT1 | ENSP00000364687 | ENSP00000417980 | euchromatic histone-lysine N-methyltransferase 2 | euchromatic histone-lysine N-methyltransferase 1; Histone methyltransferase that specifically mono- and dimethylates ’Lys-9’ of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates ’Lys-27’ of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA [...] | 0.436 |
EHMT2 | H2AFX | ENSP00000364687 | ENSP00000364310 | euchromatic histone-lysine N-methyltransferase 2 | H2A histone family, member X; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in resp [...] | 0.484 |
EHMT2 | UBC | ENSP00000364687 | ENSP00000344818 | euchromatic histone-lysine N-methyltransferase 2 | ubiquitin C | 0.835 |