Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
XPOT XPOT PUSL1 PUSL1 ADAT2 ADAT2 PUS3 PUS3 PPP2R5E PPP2R5E SAE1 SAE1 PUS1 PUS1 METTL1 METTL1 TRMT61A TRMT61A WDR4 WDR4 CALU CALU TRMT1 TRMT1 TRMT10A TRMT10A MRTO4 MRTO4 TRMT1L TRMT1L ARPC5L ARPC5L ARPC3 ARPC3 LARP1 LARP1 MKI67IP MKI67IP TRMT11 TRMT11 ZC3H14 ZC3H14 ARPC1A ARPC1A SH3GL1 SH3GL1 LARP1B LARP1B PRKACA PRKACA AARSD1 AARSD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
PUS3pseudouridylate synthase 3; Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs (By similarity) (481 aa)
ARPC3actin related protein 2/3 complex, subunit 3, 21kDa; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (178 aa)
ADAT2adenosine deaminase, tRNA-specific 2; Probably participates in deamination of adenosine-34 to inosine in many tRNAs (By similarity) (191 aa)
ZC3H14zinc finger CCCH-type containing 14 (736 aa)
ARPC5Lactin related protein 2/3 complex, subunit 5-like; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity) (153 aa)
ARPC1Aactin related protein 2/3 complex, subunit 1A, 41kDa; Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (370 aa)
SH3GL1SH3-domain GRB2-like 1; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity) (368 aa)
SAE1SUMO1 activating enzyme subunit 1; The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (346 aa)
TRMT10AtRNA methyltransferase 10 homolog A (S. cerevisiae); Probable RNA methyltransferase (By similarity) (339 aa)
MKI67IPMKI67 (FHA domain) interacting nucleolar phosphoprotein (293 aa)
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...] (351 aa)
METTL1methyltransferase like 1; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (276 aa)
LARP1BLa ribonucleoprotein domain family, member 1B (914 aa)
XPOTexportin, tRNA; Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP- bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of [...] (962 aa)
WDR4WD repeat domain 4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational change of the catalytic subunit (412 aa)
TRMT11tRNA methyltransferase 11 homolog (S. cerevisiae); Catalytic subunit of an S-adenosyl-L-methionine- dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs (By similarity) (463 aa)
LARP1La ribonucleoprotein domain family, member 1 (1019 aa)
PPP2R5Eprotein phosphatase 2, regulatory subunit B’, epsilon isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment (467 aa)
TRMT1tRNA methyltransferase 1 homolog (S. cerevisiae); Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups (659 aa)
TRMT1LtRNA methyltransferase 1 homolog (S. cerevisiae)-like; May play a role in motor coordination and exploratory behavior (By similarity) (733 aa)
MRTO4mRNA turnover 4 homolog (S. cerevisiae); Involved in mRNA turnover and ribosome assembly (By similarity) (239 aa)
PUS1pseudouridylate synthase 1; Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA (By similarity) (427 aa)
PUSL1pseudouridylate synthase-like 1 (303 aa)
TRMT61AtRNA methyltransferase 61 homolog A (S. cerevisiae); Catalytic subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (289 aa)
AARSD1alanyl-tRNA synthetase domain containing 1 (264 aa)
CALUcalumenin (323 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (25%)