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STRINGSTRING
YPEL1 YPEL1 SEC23A SEC23A RAB5A RAB5A STX8 STX8 RAB5C RAB5C SEC13 SEC13 RAB11A RAB11A SEC23B SEC23B RAB6B RAB6B STX10 STX10 STX6 STX6 RAB1A RAB1A RAB1B RAB1B YIPF5 YIPF5 RAB6A RAB6A RAB41 RAB41 RAB6C RAB6C YPEL3 YPEL3 YIF1A YIF1A YIF1B YIF1B RAB11B RAB11B RAB5B RAB5B IER3IP1 IER3IP1 YIPF6 YIPF6 YIPF2 YIPF2 YPEL2 YPEL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
YIPF2Yip1 domain family, member 2 (316 aa)
IER3IP1immediate early response 3 interacting protein 1; May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By similarity) (82 aa)
STX6syntaxin 6; Involved in intracellular vesicle trafficking (255 aa)
RAB11ARAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] (216 aa)
SEC23BSec23 homolog B (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex (By similarity) (767 aa)
RAB5ARAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension (215 aa)
YIPF5Yip1 domain family, member 5; Plays a role in transport between endoplasmic reticulum and Golgi (257 aa)
RAB41RAB41, member RAS oncogene family (221 aa)
RAB6BRAB6B, member RAS oncogene family; Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (208 aa)
STX8syntaxin 8; Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER (236 aa)
SEC23ASec23 homolog A (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex (765 aa)
RAB1BRAB1B, member RAS oncogene family; Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (201 aa)
RAB6ARAB6A, member RAS oncogene family; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity (208 aa)
SEC13SEC13 homolog (S. cerevisiae); Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (322 aa)
YPEL2yippee-like 2 (Drosophila) (119 aa)
RAB11BRAB11B, member RAS oncogene family; GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis (By similarity) (218 aa)
YPEL1yippee-like 1 (Drosophila); May play a role in epithelioid conversion of fibroblasts (119 aa)
YIF1BYip1 interacting factor homolog B (S. cerevisiae) (314 aa)
RAB5CRAB5C, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) (216 aa)
RAB5BRAB5B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) (215 aa)
YIF1AYip1 interacting factor homolog A (S. cerevisiae); Possible role in transport between endoplasmic reticulum and Golgi (293 aa)
YPEL3yippee-like 3 (Drosophila); Involved in proliferation and apoptosis in myeloid precursor cells (By similarity) (157 aa)
RAB1ARAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity (205 aa)
RAB6CRAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression (254 aa)
YIPF6Yip1 domain family, member 6 (236 aa)
STX10syntaxin 10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network (249 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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