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ZSWIM2 ZSWIM2 RLIM RLIM ENSG00000249884 ENSG00000249884 RNF165 RNF165 RNF38 RNF38 PJA2 PJA2 RSPO2 RSPO2 UBA52 UBA52 LGR5 LGR5 RNF126 RNF126 LGR6 LGR6 LGR4 LGR4 UBC UBC ZNRF3 ZNRF3 RSPO4 RSPO4 RSPO3 RSPO3 RNF122 RNF122 RNF103 RNF103 RSPO1 RSPO1 UBB UBB RPS27A RPS27A RNF115 RNF115 PJA1 PJA1 RNF215 RNF215 RNF11 RNF11 RNF149 RNF149
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
RSPO4R-spondin 4; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (By similarity) (234 aa)
RNF103ring finger protein 103; Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway (685 aa)
RNF11ring finger protein 11; Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates ’Lys-63’ polyubiquitin chains on RIPK1 and catalyzes the formation of ’Lys-48’-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leadi [...] (154 aa)
RLIMring finger protein, LIM domain interacting; E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degr [...] (624 aa)
RNF122ring finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability (155 aa)
RNF38ring finger protein 38 (515 aa)
LGR5leucine-rich repeat containing G protein-coupled receptor 5; Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicle. Target gene of Wnt signaling (907 aa)
RNF165ring finger protein 165 (346 aa)
RPS27Aribosomal protein S27a (156 aa)
RSPO2R-spondin 2; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors (By similarity) (243 aa)
RNF126ring finger protein 126 (311 aa)
ZSWIM2zinc finger, SWIM-type containing 2; E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes (By similarity) (633 aa)
RNF149ring finger protein 149; E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation (400 aa)
UBBubiquitin B (229 aa)
UBCubiquitin C (685 aa)
RSPO1R-spondin 1; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination (263 aa)
RSPO3R-spondin 3; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (By similarity) (272 aa)
PJA2praja ring finger 2, E3 ubiquitin protein ligase; Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA- mediated long-term memory processes (708 aa)
PJA1praja ring finger 1, E3 ubiquitin protein ligase; Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting (643 aa)
LGR6leucine-rich repeat containing G protein-coupled receptor 6; Orphan receptor (967 aa)
RNF115ring finger protein 115; Acts as an E2-dependent E3 ubiquitin-protein ligase. May be involved in endocytic trafficking (304 aa)
LGR4leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor (951 aa)
RNF215ring finger protein 215 (377 aa)
UBA52ubiquitin A-52 residue ribosomal protein fusion product 1 (128 aa)
ENSG00000249884RNF103-CHMP3 readthrough (221 aa)
ZNRF3zinc and ring finger 3; E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non- canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone (936 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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