node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCC1 | TMX2 | ENSP00000382342 | ENSP00000278422 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | thioredoxin-related transmembrane protein 2 | 0.644 |
CANX | TMX1 | ENSP00000247461 | ENSP00000393316 | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | thioredoxin-related transmembrane protein 1; May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions | 0.637 |
CANX | TMX2 | ENSP00000247461 | ENSP00000278422 | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | thioredoxin-related transmembrane protein 2 | 0.612 |
HNRNPU | SRSF5 | ENSP00000283179 | ENSP00000377892 | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A); Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA | serine/arginine-rich splicing factor 5; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites | 0.913 |
HNRNPU | TMX2 | ENSP00000283179 | ENSP00000278422 | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A); Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA | thioredoxin-related transmembrane protein 2 | 0.644 |
NDUFA7 | NDUFV3 | ENSP00000470609 | ENSP00000346196 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone | NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone | 0.932 |
NDUFV3 | NDUFA7 | ENSP00000346196 | ENSP00000470609 | NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone | 0.932 |
SRSF5 | HNRNPU | ENSP00000377892 | ENSP00000283179 | serine/arginine-rich splicing factor 5; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A); Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA | 0.913 |
SRSF5 | TMX2 | ENSP00000377892 | ENSP00000278422 | serine/arginine-rich splicing factor 5; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites | thioredoxin-related transmembrane protein 2 | 0.644 |
TM9SF4 | TMX2 | ENSP00000381104 | ENSP00000278422 | transmembrane 9 superfamily protein member 4 | thioredoxin-related transmembrane protein 2 | 0.668 |
TMX1 | CANX | ENSP00000393316 | ENSP00000247461 | thioredoxin-related transmembrane protein 1; May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | 0.637 |
TMX1 | TMX2 | ENSP00000393316 | ENSP00000278422 | thioredoxin-related transmembrane protein 1; May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions | thioredoxin-related transmembrane protein 2 | 0.716 |
TMX2 | ABCC1 | ENSP00000278422 | ENSP00000382342 | thioredoxin-related transmembrane protein 2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | 0.644 |
TMX2 | CANX | ENSP00000278422 | ENSP00000247461 | thioredoxin-related transmembrane protein 2 | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | 0.612 |
TMX2 | HNRNPU | ENSP00000278422 | ENSP00000283179 | thioredoxin-related transmembrane protein 2 | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A); Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA | 0.644 |
TMX2 | SRSF5 | ENSP00000278422 | ENSP00000377892 | thioredoxin-related transmembrane protein 2 | serine/arginine-rich splicing factor 5; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites | 0.644 |
TMX2 | TM9SF4 | ENSP00000278422 | ENSP00000381104 | thioredoxin-related transmembrane protein 2 | transmembrane 9 superfamily protein member 4 | 0.668 |
TMX2 | TMX1 | ENSP00000278422 | ENSP00000393316 | thioredoxin-related transmembrane protein 2 | thioredoxin-related transmembrane protein 1; May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions | 0.716 |