node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDCP1 | ST14 | ENSP00000296129 | ENSP00000278742 | CUB domain containing protein 1; May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis | suppression of tumorigenicity 14 (colon carcinoma); Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site | 0.781 |
CDCP1 | UBC | ENSP00000296129 | ENSP00000344818 | CUB domain containing protein 1; May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis | ubiquitin C | 0.483 |
ENSG00000228325 | ST14 | ENSP00000402914 | ENSP00000278742 | Uncharacterized protein | suppression of tumorigenicity 14 (colon carcinoma); Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site | 0.900 |
F2RL1 | ST14 | ENSP00000296677 | ENSP00000278742 | coagulation factor II (thrombin) receptor-like 1; Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I- kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can sig [...] | suppression of tumorigenicity 14 (colon carcinoma); Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site | 0.795 |
F2RL1 | UBC | ENSP00000296677 | ENSP00000344818 | coagulation factor II (thrombin) receptor-like 1; Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I- kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can sig [...] | ubiquitin C | 0.771 |
FAU | UBC | ENSP00000431822 | ENSP00000344818 | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | ubiquitin C | 0.887 |
FAU | UBL4A | ENSP00000431822 | ENSP00000358674 | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | ubiquitin-like 4A; Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40- it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting | 0.480 |
HGF | PLAU | ENSP00000222390 | ENSP00000361850 | hepatocyte growth factor (hepapoietin A; scatter factor) | plasminogen activator, urokinase; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin | 0.960 |
HGF | SPINT1 | ENSP00000222390 | ENSP00000342098 | hepatocyte growth factor (hepapoietin A; scatter factor) | serine peptidase inhibitor, Kunitz type 1; Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14) | 0.753 |
HGF | ST14 | ENSP00000222390 | ENSP00000278742 | hepatocyte growth factor (hepapoietin A; scatter factor) | suppression of tumorigenicity 14 (colon carcinoma); Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site | 0.642 |
IGFBP7 | ST14 | ENSP00000295666 | ENSP00000278742 | insulin-like growth factor binding protein 7; Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion | suppression of tumorigenicity 14 (colon carcinoma); Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site | 0.650 |
PDGFC | PLAU | ENSP00000422464 | ENSP00000361850 | platelet derived growth factor C; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages- inflamma [...] | plasminogen activator, urokinase; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin | 0.624 |
PDGFC | ST14 | ENSP00000422464 | ENSP00000278742 | platelet derived growth factor C; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages- inflamma [...] | suppression of tumorigenicity 14 (colon carcinoma); Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site | 0.590 |
PLAU | HGF | ENSP00000361850 | ENSP00000222390 | plasminogen activator, urokinase; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin | hepatocyte growth factor (hepapoietin A; scatter factor) | 0.960 |
PLAU | PDGFC | ENSP00000361850 | ENSP00000422464 | plasminogen activator, urokinase; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin | platelet derived growth factor C; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages- inflamma [...] | 0.624 |
PLAU | ST14 | ENSP00000361850 | ENSP00000278742 | plasminogen activator, urokinase; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin | suppression of tumorigenicity 14 (colon carcinoma); Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site | 0.618 |
PLAU | UBC | ENSP00000361850 | ENSP00000344818 | plasminogen activator, urokinase; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin | ubiquitin C | 0.441 |
SPINT1 | HGF | ENSP00000342098 | ENSP00000222390 | serine peptidase inhibitor, Kunitz type 1; Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14) | hepatocyte growth factor (hepapoietin A; scatter factor) | 0.753 |
SPINT1 | ST14 | ENSP00000342098 | ENSP00000278742 | serine peptidase inhibitor, Kunitz type 1; Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14) | suppression of tumorigenicity 14 (colon carcinoma); Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site | 0.998 |
ST14 | CDCP1 | ENSP00000278742 | ENSP00000296129 | suppression of tumorigenicity 14 (colon carcinoma); Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site | CUB domain containing protein 1; May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis | 0.781 |