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STRINGSTRING
UPB1 UPB1 KIFC1 KIFC1 KIFC2 KIFC2 KIFC3 KIFC3 NADSYN1 NADSYN1 KIF25 KIF25 GGTLC1 GGTLC1 VNN3 VNN3 MYOC MYOC NIT1 NIT1 VNN2 VNN2 BTD BTD NIT2 NIT2 VNN1 VNN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
MYOCmyocilin, trabecular meshwork inducible glucocorticoid response; May participate in the obstruction of fluid outflow in the trabecular meshwork (504 aa)
GGTLC1gamma-glutamyltransferase light chain 1 (225 aa)
KIFC2kinesin family member C2; May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites (By similarity) (838 aa)
BTDbiotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation (543 aa)
VNN2vanin 2 (520 aa)
UPB1ureidopropionase, beta; Converts N-carbamyl-beta-aminoisobutyric acid and N- carbamyl-beta-alanine to, respectively, beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide (384 aa)
NADSYN1NAD synthetase 1 (706 aa)
KIF25kinesin family member 25; Negative regulator of amino acid starvation-induced autophagy (384 aa)
VNN1vanin 1; Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine (513 aa)
NIT1nitrilase 1; Plays a role in cell growth and apoptosis- loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2 (By similarity) (327 aa)
KIFC3kinesin family member C3; Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance (833 aa)
NIT2nitrilase family, member 2; Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha- ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively. Overexpression decreases the colony-forming capacity of cultured cells by arresting cells in the G2 phase of the cell cycle (276 aa)
KIFC1kinesin family member C1 (673 aa)
VNN3vanin 3 (500 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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