node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COMMD1 | COMMD10 | ENSP00000308236 | ENSP00000274458 | copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes | COMM domain containing 10 | 0.514 |
COMMD1 | COMMD7 | ENSP00000308236 | ENSP00000278980 | copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes | COMM domain containing 7; Associates with the NF-kappa-B complex and suppresses its transcriptional activity | 0.716 |
COMMD1 | COMMD8 | ENSP00000308236 | ENSP00000370984 | copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes | COMM domain containing 8 | 0.513 |
COMMD1 | NFKB1 | ENSP00000308236 | ENSP00000226574 | copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to b [...] | 0.552 |
COMMD1 | RELA | ENSP00000308236 | ENSP00000384273 | copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes | v-rel reticuloendotheliosis viral oncogene homolog A (avian); NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most a [...] | 0.998 |
COMMD1 | UBC | ENSP00000308236 | ENSP00000344818 | copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes | ubiquitin C | 0.994 |
COMMD10 | COMMD1 | ENSP00000274458 | ENSP00000308236 | COMM domain containing 10 | copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes | 0.514 |
COMMD10 | COMMD7 | ENSP00000274458 | ENSP00000278980 | COMM domain containing 10 | COMM domain containing 7; Associates with the NF-kappa-B complex and suppresses its transcriptional activity | 0.993 |
COMMD10 | COMMD8 | ENSP00000274458 | ENSP00000370984 | COMM domain containing 10 | COMM domain containing 8 | 0.992 |
COMMD7 | COMMD1 | ENSP00000278980 | ENSP00000308236 | COMM domain containing 7; Associates with the NF-kappa-B complex and suppresses its transcriptional activity | copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes | 0.716 |
COMMD7 | COMMD10 | ENSP00000278980 | ENSP00000274458 | COMM domain containing 7; Associates with the NF-kappa-B complex and suppresses its transcriptional activity | COMM domain containing 10 | 0.993 |
COMMD7 | COMMD8 | ENSP00000278980 | ENSP00000370984 | COMM domain containing 7; Associates with the NF-kappa-B complex and suppresses its transcriptional activity | COMM domain containing 8 | 0.997 |
COMMD7 | COMMD9 | ENSP00000278980 | ENSP00000263401 | COMM domain containing 7; Associates with the NF-kappa-B complex and suppresses its transcriptional activity | COMM domain containing 9 | 0.742 |
COMMD8 | COMMD1 | ENSP00000370984 | ENSP00000308236 | COMM domain containing 8 | copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes | 0.513 |
COMMD8 | COMMD10 | ENSP00000370984 | ENSP00000274458 | COMM domain containing 8 | COMM domain containing 10 | 0.992 |
COMMD8 | COMMD7 | ENSP00000370984 | ENSP00000278980 | COMM domain containing 8 | COMM domain containing 7; Associates with the NF-kappa-B complex and suppresses its transcriptional activity | 0.997 |
COMMD8 | UBC | ENSP00000370984 | ENSP00000344818 | COMM domain containing 8 | ubiquitin C | 0.721 |
COMMD9 | COMMD7 | ENSP00000263401 | ENSP00000278980 | COMM domain containing 9 | COMM domain containing 7; Associates with the NF-kappa-B complex and suppresses its transcriptional activity | 0.742 |
COMMD9 | UBC | ENSP00000263401 | ENSP00000344818 | COMM domain containing 9 | ubiquitin C | 0.483 |
NFKB1 | COMMD1 | ENSP00000226574 | ENSP00000308236 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to b [...] | copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes | 0.552 |