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STRINGSTRING
IGF2R IGF2R RGP1 RGP1 M6PR M6PR RAB9A RAB9A RAB9B RAB9B GOLGA1 GOLGA1 GOLGA4 GOLGA4 GCC2 GCC2 GCC1 GCC1 NSF NSF NAPG NAPG STX16 STX16 ARL1 ARL1 VAMP3 VAMP3 STX6 STX6 ARFRP1 ARFRP1 RAB6A RAB6A VPS51 VPS51 COG6 COG6 TMF1 TMF1 COG7 COG7 COG1 COG1 COG3 COG3 COG4 COG4 COG2 COG2 COG5 COG5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
M6PRmannose-6-phosphate receptor (cation dependent); Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex (277 aa)
VAMP3vesicle-associated membrane protein 3; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network (100 aa)
RAB9BRAB9B, member RAS oncogene family; Involved in the transport of proteins between the endosomes and the trans Golgi network (By similarity) (201 aa)
STX6syntaxin 6; Involved in intracellular vesicle trafficking (255 aa)
COG3component of oligomeric golgi complex 3; Involved in ER-Golgi transport (828 aa)
ARL1ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (181 aa)
VPS51vacuolar protein sorting 51 homolog (S. cerevisiae); Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi networkl (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN (782 aa)
COG5component of oligomeric golgi complex 5; Required for normal Golgi function (By similarity) (860 aa)
COG1component of oligomeric golgi complex 1; Required for normal Golgi function (By similarity) (980 aa)
COG7component of oligomeric golgi complex 7; Required for normal Golgi function (By similarity) (770 aa)
GCC2GRIP and coiled-coil domain containing 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 (1684 aa)
RAB6ARAB6A, member RAS oncogene family; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity (208 aa)
COG4component of oligomeric golgi complex 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1 (789 aa)
GCC1GRIP and coiled-coil domain containing 1; Probably involved in maintaining Golgi structure (775 aa)
NAPGN-ethylmaleimide-sensitive factor attachment protein, gamma; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (312 aa)
ARFRP1ADP-ribosylation factor related protein 1; Possibly involved in plasma membrane-related signaling events (201 aa)
GOLGA4golgin A4; May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1 (2243 aa)
IGF2Rinsulin-like growth factor 2 receptor; Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4 (2491 aa)
COG2component of oligomeric golgi complex 2; Required for normal Golgi morphology and function (738 aa)
STX16syntaxin 16 (325 aa)
GOLGA1golgin A1; Probably involved in maintaining Golgi structure (767 aa)
RGP1RGP1 retrograde golgi transport homolog (S. cerevisiae) (391 aa)
NSFN-ethylmaleimide-sensitive factor; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seem to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity) (744 aa)
TMF1TATA element modulatory factor 1; Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes- one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP) (1093 aa)
COG6component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) (657 aa)
RAB9ARAB9A, member RAS oncogene family; Involved in the transport of proteins between the endosomes and the trans Golgi network (201 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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