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IFT88 IFT88 FLJ00362 FLJ00362 SALL1 SALL1 CDK12 CDK12 CDC5L CDC5L CDKN1A CDKN1A VPS51 VPS51 VPS52 VPS52 KXD1 KXD1 COG8 COG8 VPS53 VPS53 SALL4 SALL4 YTHDC1 YTHDC1 UBC UBC VPS54 VPS54 STX10 STX10 SALL3 SALL3 VAMP4 VAMP4 STX6 STX6 RTEL1 RTEL1 VTI1A VTI1A STX5 STX5 GOSR2 GOSR2 BRIP1 BRIP1 VTI1B VTI1B ENSG00000262633 ENSG00000262633
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
SALL4sal-like 4 (Drosophila); Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells (1053 aa)
KXD1KxDL motif containing 1; Involved in endosomal cargo sorting (By similarity) (176 aa)
GOSR2golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network (213 aa)
VAMP4vesicle-associated membrane protein 4; Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule (141 aa)
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (164 aa)
SALL1sal-like 1 (Drosophila); Transcriptional repressor involved in organogenesis (By similarity) (1324 aa)
STX6syntaxin 6; Involved in intracellular vesicle trafficking (255 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1; DNA-dependent ATPase and 5’ to 3’ DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (1249 aa)
VPS54vacuolar protein sorting 54 homolog (S. cerevisiae); May be involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (977 aa)
VPS51vacuolar protein sorting 51 homolog (S. cerevisiae); Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi networkl (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN (782 aa)
STX5syntaxin 5; Mediates endoplasmic reticulum to Golgi transport (By similarity) (355 aa)
COG8component of oligomeric golgi complex 8; Required for normal Golgi function (By similarity) (612 aa)
IFT88intraflagellar transport 88 homolog (Chlamydomonas); Involved in primary cilium biogenesis (By similarity) (833 aa)
YTHDC1YTH domain containing 1; May be part of a signal transduction pathway that influences splice site selection (By similarity) (727 aa)
UBCubiquitin C (685 aa)
RTEL1regulator of telomere elongation helicase 1 (1219 aa)
CDC5LCDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (802 aa)
VTI1Avesicle transport through interaction with t-SNAREs homolog 1A (yeast); V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with [...] (217 aa)
CDK12cyclin-dependent kinase 12; Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors (1490 aa)
VPS53vacuolar protein sorting 53 homolog (S. cerevisiae); May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (832 aa)
VPS52vacuolar protein sorting 52 homolog (S. cerevisiae); May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (723 aa)
SALL3sal-like 3 (Drosophila); Probable transcription factor (1300 aa)
VTI1Bvesicle transport through interaction with t-SNAREs homolog 1B (yeast); V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence (232 aa)
FLJ00362RTEL1-TNFRSF6B readthrough (non-protein coding) (1400 aa)
ENSG00000262633Golgi SNAP receptor complex member 2; Uncharacterized protein (232 aa)
STX10syntaxin 10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network (249 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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