node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABL1 | GRB2 | ENSP00000361423 | ENSP00000339007 | c-abl oncogene 1, non-receptor tyrosine kinase; Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN ( [...] | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.999 |
ABL1 | TRAF6 | ENSP00000361423 | ENSP00000337853 | c-abl oncogene 1, non-receptor tyrosine kinase; Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN ( [...] | TNF receptor-associated factor 6, E3 ubiquitin protein ligase; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of ’Lys-63’-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF- kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Ad [...] | 0.714 |
ABL1 | UBC | ENSP00000361423 | ENSP00000344818 | c-abl oncogene 1, non-receptor tyrosine kinase; Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN ( [...] | ubiquitin C | 0.902 |
CEP57 | UBC | ENSP00000317902 | ENSP00000344818 | centrosomal protein 57kDa; Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring- like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1 | ubiquitin C | 0.721 |
CTAGE5 | DGCR6 | ENSP00000280083 | ENSP00000331681 | CTAGE family, member 5 | DiGeorge syndrome critical region gene 6; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches | 0.572 |
CTAGE5 | MAGEB18 | ENSP00000280083 | ENSP00000314543 | CTAGE family, member 5 | melanoma antigen family B, 18; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex | 0.534 |
CTAGE5 | RASAL2 | ENSP00000280083 | ENSP00000356621 | CTAGE family, member 5 | RAS protein activator like 2; Inhibitory regulator of the Ras-cyclic AMP pathway | 0.539 |
DGCR6 | CTAGE5 | ENSP00000331681 | ENSP00000280083 | DiGeorge syndrome critical region gene 6; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches | CTAGE family, member 5 | 0.572 |
DGCR6 | SS18L1 | ENSP00000331681 | ENSP00000333012 | DiGeorge syndrome critical region gene 6; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches | synovial sarcoma translocation gene on chromosome 18-like 1 | 0.572 |
GRB2 | ABL1 | ENSP00000339007 | ENSP00000361423 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | c-abl oncogene 1, non-receptor tyrosine kinase; Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN ( [...] | 0.999 |
GRB2 | RASAL2 | ENSP00000339007 | ENSP00000356621 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | RAS protein activator like 2; Inhibitory regulator of the Ras-cyclic AMP pathway | 0.464 |
GRB2 | UBC | ENSP00000339007 | ENSP00000344818 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | ubiquitin C | 0.949 |
MAGEB18 | CTAGE5 | ENSP00000314543 | ENSP00000280083 | melanoma antigen family B, 18; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex | CTAGE family, member 5 | 0.534 |
RASAL2 | CTAGE5 | ENSP00000356621 | ENSP00000280083 | RAS protein activator like 2; Inhibitory regulator of the Ras-cyclic AMP pathway | CTAGE family, member 5 | 0.539 |
RASAL2 | GRB2 | ENSP00000356621 | ENSP00000339007 | RAS protein activator like 2; Inhibitory regulator of the Ras-cyclic AMP pathway | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.464 |
RASAL2 | UBC | ENSP00000356621 | ENSP00000344818 | RAS protein activator like 2; Inhibitory regulator of the Ras-cyclic AMP pathway | ubiquitin C | 0.548 |
SS18L1 | DGCR6 | ENSP00000333012 | ENSP00000331681 | synovial sarcoma translocation gene on chromosome 18-like 1 | DiGeorge syndrome critical region gene 6; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches | 0.572 |
TRAF6 | ABL1 | ENSP00000337853 | ENSP00000361423 | TNF receptor-associated factor 6, E3 ubiquitin protein ligase; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of ’Lys-63’-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF- kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Ad [...] | c-abl oncogene 1, non-receptor tyrosine kinase; Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN ( [...] | 0.714 |
TRAF6 | UBC | ENSP00000337853 | ENSP00000344818 | TNF receptor-associated factor 6, E3 ubiquitin protein ligase; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of ’Lys-63’-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF- kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Ad [...] | ubiquitin C | 0.999 |
UBC | ABL1 | ENSP00000344818 | ENSP00000361423 | ubiquitin C | c-abl oncogene 1, non-receptor tyrosine kinase; Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN ( [...] | 0.902 |