7 items (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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protein of unknown 3D structure

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query proteins and first shell of interactors

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second shell of interactors

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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Your Input:
	CDC6	cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated (560 aa)
	ORC3	origin recognition complex, subunit 3 (712 aa)
	ORC4	origin recognition complex, subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (436 aa)
	BTBD11	BTB (POZ) domain containing 11 (1104 aa)
	CDT1	chromatin licensing and DNA replication factor 1; Cooperates with CDC6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene (546 aa)
	ORC1	origin recognition complex, subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (861 aa)
	ALKBH6	alkB, alkylation repair homolog 6 (E. coli); Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity) (266 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALKBH6	BTBD11	ENSP00000368152	ENSP00000280758	alkB, alkylation repair homolog 6 (E. coli); Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity)	BTB (POZ) domain containing 11	0.571
BTBD11	ALKBH6	ENSP00000280758	ENSP00000368152	BTB (POZ) domain containing 11	alkB, alkylation repair homolog 6 (E. coli); Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity)	0.571
CDC6	CDT1	ENSP00000209728	ENSP00000301019	cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated	chromatin licensing and DNA replication factor 1; Cooperates with CDC6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene	0.999
CDC6	ORC1	ENSP00000209728	ENSP00000360621	cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated	origin recognition complex, subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication	0.999
CDC6	ORC3	ENSP00000209728	ENSP00000257789	cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated	origin recognition complex, subunit 3	0.999
CDC6	ORC4	ENSP00000209728	ENSP00000264169	cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated	origin recognition complex, subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication	0.999
CDT1	CDC6	ENSP00000301019	ENSP00000209728	chromatin licensing and DNA replication factor 1; Cooperates with CDC6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene	cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated	0.999
CDT1	ORC1	ENSP00000301019	ENSP00000360621	chromatin licensing and DNA replication factor 1; Cooperates with CDC6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene	origin recognition complex, subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication	0.998
CDT1	ORC3	ENSP00000301019	ENSP00000257789	chromatin licensing and DNA replication factor 1; Cooperates with CDC6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene	origin recognition complex, subunit 3	0.951
CDT1	ORC4	ENSP00000301019	ENSP00000264169	chromatin licensing and DNA replication factor 1; Cooperates with CDC6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene	origin recognition complex, subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication	0.942
ORC1	CDC6	ENSP00000360621	ENSP00000209728	origin recognition complex, subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication	cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated	0.999
ORC1	CDT1	ENSP00000360621	ENSP00000301019	origin recognition complex, subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication	chromatin licensing and DNA replication factor 1; Cooperates with CDC6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene	0.998
ORC1	ORC3	ENSP00000360621	ENSP00000257789	origin recognition complex, subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication	origin recognition complex, subunit 3	0.999
ORC1	ORC4	ENSP00000360621	ENSP00000264169	origin recognition complex, subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication	origin recognition complex, subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication	0.999
ORC3	CDC6	ENSP00000257789	ENSP00000209728	origin recognition complex, subunit 3	cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated	0.999
ORC3	CDT1	ENSP00000257789	ENSP00000301019	origin recognition complex, subunit 3	chromatin licensing and DNA replication factor 1; Cooperates with CDC6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene	0.951
ORC3	ORC1	ENSP00000257789	ENSP00000360621	origin recognition complex, subunit 3	origin recognition complex, subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication	0.999
ORC3	ORC4	ENSP00000257789	ENSP00000264169	origin recognition complex, subunit 3	origin recognition complex, subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication	0.999
ORC4	CDC6	ENSP00000264169	ENSP00000209728	origin recognition complex, subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication	cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated	0.999
ORC4	CDT1	ENSP00000264169	ENSP00000301019	origin recognition complex, subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication	chromatin licensing and DNA replication factor 1; Cooperates with CDC6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene	0.942

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