node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APC | UBC | ENSP00000257430 | ENSP00000344818 | adenomatous polyposis coli; Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of M [...] | ubiquitin C | 0.954 |
CGNL1 | UBC | ENSP00000281282 | ENSP00000344818 | cingulin-like 1; May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons (By similarity) | ubiquitin C | 0.483 |
SUMO2 | UBC | ENSP00000405965 | ENSP00000344818 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] | ubiquitin C | 0.999 |
SUMO2 | YWHAE | ENSP00000405965 | ENSP00000264335 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 0.473 |
SUMO2 | YWHAZ | ENSP00000405965 | ENSP00000309503 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.567 |
UBC | APC | ENSP00000344818 | ENSP00000257430 | ubiquitin C | adenomatous polyposis coli; Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of M [...] | 0.954 |
UBC | CGNL1 | ENSP00000344818 | ENSP00000281282 | ubiquitin C | cingulin-like 1; May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons (By similarity) | 0.483 |
UBC | SUMO2 | ENSP00000344818 | ENSP00000405965 | ubiquitin C | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] | 0.999 |
UBC | WNK1 | ENSP00000344818 | ENSP00000313059 | ubiquitin C | WNK lysine deficient protein kinase 1 | 0.963 |
UBC | YWHAE | ENSP00000344818 | ENSP00000264335 | ubiquitin C | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 0.996 |
UBC | YWHAG | ENSP00000344818 | ENSP00000306330 | ubiquitin C | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner | 0.994 |
UBC | YWHAZ | ENSP00000344818 | ENSP00000309503 | ubiquitin C | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.995 |
WNK1 | UBC | ENSP00000313059 | ENSP00000344818 | WNK lysine deficient protein kinase 1 | ubiquitin C | 0.963 |
YWHAE | SUMO2 | ENSP00000264335 | ENSP00000405965 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] | 0.473 |
YWHAE | UBC | ENSP00000264335 | ENSP00000344818 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | ubiquitin C | 0.996 |
YWHAE | YWHAG | ENSP00000264335 | ENSP00000306330 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner | 0.984 |
YWHAE | YWHAZ | ENSP00000264335 | ENSP00000309503 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.999 |
YWHAG | UBC | ENSP00000306330 | ENSP00000344818 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner | ubiquitin C | 0.994 |
YWHAG | YWHAE | ENSP00000306330 | ENSP00000264335 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 0.984 |
YWHAG | YWHAZ | ENSP00000306330 | ENSP00000309503 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.962 |