node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATF2 | ATF7 | ENSP00000264110 | ENSP00000329212 | activating transcription factor 2; Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus- 5’- GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex | activating transcription factor 7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AG][AG]- 3’), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family | 0.588 |
ATF2 | CREB1 | ENSP00000264110 | ENSP00000387699 | activating transcription factor 2; Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus- 5’- GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | 0.988 |
ATF2 | CREM | ENSP00000264110 | ENSP00000265372 | activating transcription factor 2; Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus- 5’- GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex | cAMP responsive element modulator | 0.956 |
ATF2 | SRF | ENSP00000264110 | ENSP00000265354 | activating transcription factor 2; Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus- 5’- GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex | serum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation | 0.794 |
ATF2 | UBC | ENSP00000264110 | ENSP00000344818 | activating transcription factor 2; Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus- 5’- GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex | ubiquitin C | 0.533 |
ATF7 | ATF2 | ENSP00000329212 | ENSP00000264110 | activating transcription factor 7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AG][AG]- 3’), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family | activating transcription factor 2; Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus- 5’- GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex | 0.588 |
ATF7 | CREB1 | ENSP00000329212 | ENSP00000387699 | activating transcription factor 7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AG][AG]- 3’), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | 0.903 |
ATF7 | CREM | ENSP00000329212 | ENSP00000265372 | activating transcription factor 7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AG][AG]- 3’), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family | cAMP responsive element modulator | 0.699 |
ATF7 | SRF | ENSP00000329212 | ENSP00000265354 | activating transcription factor 7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AG][AG]- 3’), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family | serum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation | 0.637 |
ATF7 | UBC | ENSP00000329212 | ENSP00000344818 | activating transcription factor 7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AG][AG]- 3’), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family | ubiquitin C | 0.529 |
BARX2 | CREB1 | ENSP00000281437 | ENSP00000387699 | BARX homeobox 2; Transcription factor. Binds optimally to the DNA consensus sequence 5’-YYTAATGRTTTTY-3’. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity) | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | 0.880 |
BARX2 | SRF | ENSP00000281437 | ENSP00000265354 | BARX homeobox 2; Transcription factor. Binds optimally to the DNA consensus sequence 5’-YYTAATGRTTTTY-3’. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity) | serum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation | 0.627 |
BARX2 | TBL1X | ENSP00000281437 | ENSP00000217964 | BARX homeobox 2; Transcription factor. Binds optimally to the DNA consensus sequence 5’-YYTAATGRTTTTY-3’. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity) | transducin (beta)-like 1X-linked; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange | 0.652 |
BARX2 | TBL1Y | ENSP00000281437 | ENSP00000328879 | BARX homeobox 2; Transcription factor. Binds optimally to the DNA consensus sequence 5’-YYTAATGRTTTTY-3’. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity) | transducin (beta)-like 1, Y-linked; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity) | 0.648 |
CREB1 | ATF2 | ENSP00000387699 | ENSP00000264110 | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | activating transcription factor 2; Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus- 5’- GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex | 0.988 |
CREB1 | ATF7 | ENSP00000387699 | ENSP00000329212 | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | activating transcription factor 7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AG][AG]- 3’), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family | 0.903 |
CREB1 | BARX2 | ENSP00000387699 | ENSP00000281437 | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | BARX homeobox 2; Transcription factor. Binds optimally to the DNA consensus sequence 5’-YYTAATGRTTTTY-3’. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity) | 0.880 |
CREB1 | CREM | ENSP00000387699 | ENSP00000265372 | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | cAMP responsive element modulator | 0.962 |
CREB1 | SRF | ENSP00000387699 | ENSP00000265354 | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | serum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation | 0.905 |
CREB1 | TLE1 | ENSP00000387699 | ENSP00000365682 | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG | 0.497 |