node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CNOT4 | UBC | ENSP00000445508 | ENSP00000344818 | CCR4-NOT transcription complex, subunit 4 | ubiquitin C | 0.811 |
COX18 | GUF1 | ENSP00000295890 | ENSP00000281543 | cytochrome c oxidase assembly homolog 18 (yeast); Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space | GUF1 GTPase homolog (S. cerevisiae); Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner (By similarity) | 0.443 |
ERCC4 | FANCM | ENSP00000310520 | ENSP00000267430 | excision repair cross-complementing rodent repair deficiency, complementation group 4; Structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link | Fanconi anemia, complementation group M; ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions | 0.850 |
ERCC4 | UBC | ENSP00000310520 | ENSP00000344818 | excision repair cross-complementing rodent repair deficiency, complementation group 4; Structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link | ubiquitin C | 0.620 |
FANCM | ERCC4 | ENSP00000267430 | ENSP00000310520 | Fanconi anemia, complementation group M; ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions | excision repair cross-complementing rodent repair deficiency, complementation group 4; Structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link | 0.850 |
FANCM | UBC | ENSP00000267430 | ENSP00000344818 | Fanconi anemia, complementation group M; ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions | ubiquitin C | 0.931 |
GUF1 | COX18 | ENSP00000281543 | ENSP00000295890 | GUF1 GTPase homolog (S. cerevisiae); Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner (By similarity) | cytochrome c oxidase assembly homolog 18 (yeast); Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space | 0.443 |
GUF1 | MRPL11 | ENSP00000281543 | ENSP00000308897 | GUF1 GTPase homolog (S. cerevisiae); Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner (By similarity) | mitochondrial ribosomal protein L11 | 0.836 |
GUF1 | MRPS12 | ENSP00000281543 | ENSP00000308845 | GUF1 GTPase homolog (S. cerevisiae); Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner (By similarity) | mitochondrial ribosomal protein S12 | 0.829 |
GUF1 | OXA1L | ENSP00000281543 | ENSP00000285848 | GUF1 GTPase homolog (S. cerevisiae); Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner (By similarity) | oxidase (cytochrome c) assembly 1-like; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria | 0.502 |
GUF1 | RPL12 | ENSP00000281543 | ENSP00000354739 | GUF1 GTPase homolog (S. cerevisiae); Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner (By similarity) | ribosomal protein L12; Binds directly to 26S ribosomal RNA (By similarity) | 0.786 |
GUF1 | RPS23 | ENSP00000281543 | ENSP00000296674 | GUF1 GTPase homolog (S. cerevisiae); Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner (By similarity) | ribosomal protein S23 | 0.776 |
MRPL11 | GUF1 | ENSP00000308897 | ENSP00000281543 | mitochondrial ribosomal protein L11 | GUF1 GTPase homolog (S. cerevisiae); Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner (By similarity) | 0.836 |
MRPL11 | MRPS12 | ENSP00000308897 | ENSP00000308845 | mitochondrial ribosomal protein L11 | mitochondrial ribosomal protein S12 | 0.986 |
MRPL11 | RPS23 | ENSP00000308897 | ENSP00000296674 | mitochondrial ribosomal protein L11 | ribosomal protein S23 | 0.977 |
MRPL11 | UBC | ENSP00000308897 | ENSP00000344818 | mitochondrial ribosomal protein L11 | ubiquitin C | 0.632 |
MRPS12 | GUF1 | ENSP00000308845 | ENSP00000281543 | mitochondrial ribosomal protein S12 | GUF1 GTPase homolog (S. cerevisiae); Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner (By similarity) | 0.829 |
MRPS12 | MRPL11 | ENSP00000308845 | ENSP00000308897 | mitochondrial ribosomal protein S12 | mitochondrial ribosomal protein L11 | 0.986 |
MRPS12 | RPL12 | ENSP00000308845 | ENSP00000354739 | mitochondrial ribosomal protein S12 | ribosomal protein L12; Binds directly to 26S ribosomal RNA (By similarity) | 0.979 |
MRPS12 | UBC | ENSP00000308845 | ENSP00000344818 | mitochondrial ribosomal protein S12 | ubiquitin C | 0.759 |