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ATF7IP | activating transcription factor 7 interacting protein; Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 ’Lys-9’ (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcr [...] (1270 aa) | |||
EPG5 | ectopic P-granules autophagy protein 5 homolog (C. elegans); Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo (2579 aa) |