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ESX1 ESX1 LMO3 LMO3 PRRX2 PRRX2 SCN8A SCN8A DPRX DPRX KRT81 KRT81 TLE4 TLE4 COMP COMP KCNK16 KCNK16 GSC2 GSC2 OTP OTP MAFA MAFA OTX1 OTX1 LMX1B LMX1B SHOX SHOX LHX5 LHX5 TNPO3 TNPO3 KRTAP26-1 KRTAP26-1 FBLN5 FBLN5 ISL2 ISL2 KRTAP1-5 KRTAP1-5 SPRY1 SPRY1 ARX ARX RHOXF2B RHOXF2B DRGX DRGX LHX1 LHX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
GSC2goosecoid homeobox 2; May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC (205 aa)
COMPcartilage oligomeric matrix protein; May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BI [...] (757 aa)
LHX1LIM homeobox 1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (406 aa)
LHX5LIM homeobox 5; Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system (402 aa)
TNPO3transportin 3; Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains (923 aa)
OTX1orthodenticle homeobox 1; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS)- 5’-TCTAATCCC-3’ (354 aa)
ISL2ISL LIM homeobox 2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways (By similarity) (359 aa)
OTPorthopedia homeobox; Probably involved in the differentiation of hypothalamic neuroendocrine cells (325 aa)
LMO3LIM domain only 3 (rhombotin-like 2) (145 aa)
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian); Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context (353 aa)
SPRY1sprouty homolog 1, antagonist of FGF signaling (Drosophila); May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis (319 aa)
FBLN5fibulin 5; Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling (448 aa)
SCN8Asodium channel, voltage gated, type VIII, alpha subunit; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation (1980 aa)
LMX1BLIM homeobox transcription factor 1, beta; Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels (406 aa)
KRTAP26-1keratin associated protein 26-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (210 aa)
KRTAP1-5keratin associated protein 1-5; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (174 aa)
RHOXF2BRhox homeobox family, member 2B (288 aa)
PRRX2paired related homeobox 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development (253 aa)
ESX1ESX homeobox 1; May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5’-TAATGTTATTA-3’ which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover (406 aa)
TLE4transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) (773 aa)
DPRXdivergent-paired related homeobox; Putative transcription factor (By similarity) (191 aa)
ARXaristaless related homeobox; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate (562 aa)
KRT81keratin 81 (505 aa)
SHOXshort stature homeobox; Controls fundamental aspects of growth and development (292 aa)
KCNK16potassium channel, subfamily K, member 16; Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents (322 aa)
DRGXdorsal root ganglia homeobox; Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain (By similarity) (268 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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