node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHM | CHML | ENSP00000350386 | ENSP00000355511 | choroideremia (Rab escort protein 1); Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Also a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation | choroideremia-like (Rab escort protein 2); Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than REP-1 in supporting prenylation of Rab3 family | 0.724 |
CHML | CHM | ENSP00000355511 | ENSP00000350386 | choroideremia-like (Rab escort protein 2); Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than REP-1 in supporting prenylation of Rab3 family | choroideremia (Rab escort protein 1); Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Also a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation | 0.724 |
DOC2B | RAB3C | ENSP00000343665 | ENSP00000282878 | double C2-like domains, beta; Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes [...] | RAB3C, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | 0.795 |
FKBP2 | RAB3C | ENSP00000310935 | ENSP00000282878 | FK506 binding protein 2, 13kDa; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides | RAB3C, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | 0.575 |
GDI1 | RAB3C | ENSP00000394071 | ENSP00000282878 | GDP dissociation inhibitor 1; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | RAB3C, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | 0.526 |
GDI2 | RAB3C | ENSP00000369538 | ENSP00000282878 | GDP dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | RAB3C, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | 0.609 |
IFT27 | RAB3C | ENSP00000393541 | ENSP00000282878 | intraflagellar transport 27 homolog (Chlamydomonas); Possesses GTPase activity (By similarity) | RAB3C, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | 0.607 |
MLPH | RPH3A | ENSP00000264605 | ENSP00000374036 | melanophilin; Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A | rabphilin 3A homolog (mouse); Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity) | 0.835 |
PCLO | RIMS2 | ENSP00000334319 | ENSP00000384892 | piccolo (presynaptic cytomatrix protein) | regulating synaptic membrane exocytosis 2; Rab effector involved in exocytosis. May act as scaffold protein | 0.872 |
RAB35 | RAB3C | ENSP00000229340 | ENSP00000282878 | RAB35, member RAS oncogene family; In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge | RAB3C, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | 0.686 |
RAB3C | DOC2B | ENSP00000282878 | ENSP00000343665 | RAB3C, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | double C2-like domains, beta; Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes [...] | 0.795 |
RAB3C | FKBP2 | ENSP00000282878 | ENSP00000310935 | RAB3C, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | FK506 binding protein 2, 13kDa; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides | 0.575 |
RAB3C | GDI1 | ENSP00000282878 | ENSP00000394071 | RAB3C, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | GDP dissociation inhibitor 1; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | 0.526 |
RAB3C | GDI2 | ENSP00000282878 | ENSP00000369538 | RAB3C, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | GDP dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | 0.609 |
RAB3C | IFT27 | ENSP00000282878 | ENSP00000393541 | RAB3C, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | intraflagellar transport 27 homolog (Chlamydomonas); Possesses GTPase activity (By similarity) | 0.607 |
RAB3C | RAB35 | ENSP00000282878 | ENSP00000229340 | RAB3C, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | RAB35, member RAS oncogene family; In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge | 0.686 |
RAB3C | RABIF | ENSP00000282878 | ENSP00000356231 | RAB3C, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | RAB interacting factor; Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1 and RAB3A, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport | 0.486 |
RAB3C | RIMS1 | ENSP00000282878 | ENSP00000428417 | RAB3C, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | regulating synaptic membrane exocytosis 1 | 0.694 |
RAB3C | RIMS2 | ENSP00000282878 | ENSP00000384892 | RAB3C, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | regulating synaptic membrane exocytosis 2; Rab effector involved in exocytosis. May act as scaffold protein | 0.929 |
RAB3C | RPH3A | ENSP00000282878 | ENSP00000374036 | RAB3C, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | rabphilin 3A homolog (mouse); Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity) | 0.955 |