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RCCD1 RCCD1 BRIP1 BRIP1 ABCB7 ABCB7 NARFL NARFL RTEL1 RTEL1 NDN NDN MMS19 MMS19 FAM96B FAM96B ERCC2 ERCC2 UBQLN1 UBQLN1 CIAO1 CIAO1 DCTPP1 DCTPP1 NARF NARF NUBP1 NUBP1 UBC UBC GNPDA1 GNPDA1 HK2 HK2 API5 API5 PDLIM1 PDLIM1 XPNPEP1 XPNPEP1 STK39 STK39 ARIH2 ARIH2 FKBP9 FKBP9 EHD1 EHD1 DFFB DFFB NOL3 NOL3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
FKBP9FK506 binding protein 9, 63 kDa; PPIases accelerate the folding of proteins during protein synthesis (570 aa)
NARFLnuclear prelamin A recognition factor-like; Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect (476 aa)
ABCB7ATP-binding cassette, sub-family B (MDR/TAP), member 7; Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins (753 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1; DNA-dependent ATPase and 5’ to 3’ DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (1249 aa)
NOL3nucleolar protein 3 (apoptosis repressor with CARD domain); Isoform 1 may be involved in RNA splicing (208 aa)
NUBP1nucleotide binding protein 1; Implicated in the regulation of centrosome duplication (By similarity). Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (320 aa)
HK2hexokinase 2 (917 aa)
NARFnuclear prelamin A recognition factor (456 aa)
GNPDA1glucosamine-6-phosphate deaminase 1; Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity) (289 aa)
EHD1EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (534 aa)
DCTPP1dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non- canonical nucleotide triphosphates. May protect cells a [...] (170 aa)
NDNnecdin homolog (mouse); Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle- promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity) (321 aa)
UBCubiquitin C (685 aa)
STK39serine threonine kinase 39; May act as a mediator of stress-activated signals (545 aa)
ARIH2ariadne homolog 2 (Drosophila); E3 ubiquitin-protein ligase mediating ’Lys-48’-and ’Lys- 63’-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis (493 aa)
RTEL1regulator of telomere elongation helicase 1 (1219 aa)
MMS19MMS19 nucleotide excision repair homolog (S. cerevisiae) (1030 aa)
PDLIM1PDZ and LIM domain 1; Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (329 aa)
UBQLN1ubiquilin 1; Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors (By similarity). Promotes the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has no effect on PSEN1 and PSEN2 degradation (589 aa)
DFFBDNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology (338 aa)
ERCC2excision repair cross-complementing rodent repair deficiency, complementation group 2; ATP-dependent 5’-3’ DNA helicase, component of the core- TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might h [...] (760 aa)
RCCD1RCC1 domain containing 1 (376 aa)
FAM96Bfamily with sequence similarity 96, member B; Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD (163 aa)
CIAO1cytosolic iron-sulfur protein assembly 1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (339 aa)
XPNPEP1X-prolyl aminopeptidase (aminopeptidase P) 1, soluble; Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (666 aa)
API5apoptosis inhibitor 5; Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs (524 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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