node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CIRH1A | FBL | ENSP00000327179 | ENSP00000221801 | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV | fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA | 0.916 |
CIRH1A | HEATR1 | ENSP00000327179 | ENSP00000355541 | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV | HEAT repeat containing 1; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity) | 0.988 |
CIRH1A | MPHOSPH10 | ENSP00000327179 | ENSP00000244230 | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV | M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing | 0.985 |
CIRH1A | NHP2L1 | ENSP00000327179 | ENSP00000215956 | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV | NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae); Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding | 0.839 |
CIRH1A | NOL11 | ENSP00000327179 | ENSP00000253247 | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV | nucleolar protein 11 | 0.978 |
CIRH1A | NOP14 | ENSP00000327179 | ENSP00000315674 | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV | NOP14 nucleolar protein homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity) | 0.991 |
CIRH1A | NOP58 | ENSP00000327179 | ENSP00000264279 | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV | NOP58 ribonucleoprotein homolog (yeast); Required for 60S ribosomal subunit biogenesis (By similarity) | 0.943 |
CIRH1A | PDCD11 | ENSP00000327179 | ENSP00000358812 | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV | programmed cell death 11; Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA | 0.967 |
CIRH1A | PWP2 | ENSP00000327179 | ENSP00000291576 | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV | PWP2 periodic tryptophan protein homolog (yeast) | 0.997 |
CIRH1A | RCL1 | ENSP00000327179 | ENSP00000371169 | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV | RNA terminal phosphate cyclase-like 1; Does not have cyclase activity. Plays a role in 40S- ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity) | 0.951 |
CIRH1A | RIOK2 | ENSP00000327179 | ENSP00000283109 | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV | RIO kinase 2 (yeast) | 0.540 |
CIRH1A | UTP14A | ENSP00000327179 | ENSP00000377944 | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV | UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast); May be required for ribosome biogenesis (By similarity) | 0.942 |
CIRH1A | UTP14C | ENSP00000327179 | ENSP00000428619 | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV | UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast); Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By similarity) | 0.957 |
CIRH1A | UTP15 | ENSP00000327179 | ENSP00000296792 | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV | UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) | 0.993 |
CIRH1A | UTP18 | ENSP00000327179 | ENSP00000225298 | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV | UTP18 small subunit (SSU) processome component homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) | 0.985 |
CIRH1A | UTP6 | ENSP00000327179 | ENSP00000261708 | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV | UTP6, small subunit (SSU) processome component, homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) | 0.989 |
CIRH1A | WDR36 | ENSP00000327179 | ENSP00000423067 | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV | WD repeat domain 36; Involved in T-cell activation and highly co-regulated with IL2 | 0.994 |
CIRH1A | WDR46 | ENSP00000327179 | ENSP00000363746 | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV | WD repeat domain 46 | 0.967 |
FBL | CIRH1A | ENSP00000221801 | ENSP00000327179 | fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA | cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV | 0.916 |
FBL | HEATR1 | ENSP00000221801 | ENSP00000355541 | fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA | HEAT repeat containing 1; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity) | 0.978 |