Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | ACR | acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome (421 aa) | ||
 | PRSS54 | protease, serine, 54 (395 aa) | ||
 | TNN | tenascin N; Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity) (1299 aa) | ||
 | FLRT1 | fibronectin leucine rich transmembrane protein 1; May have a function in cell adhesion and/or receptor signaling (674 aa) | ||
 | ENSG00000269741 | Kallikrein-9 (250 aa) | ||
 | TNR | tenascin R; Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repuls [...] (1358 aa) | ||
 | LTK | leukocyte receptor tyrosine kinase; Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport (864 aa) | ||
 | TNC | tenascin C; Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6 (2201 aa) | ||
 | PAMR1 | peptidase domain containing associated with muscle regeneration 1; May play a role in regeneration of skeletal muscle (By similarity) (737 aa) | ||
 | GPR115 | G protein-coupled receptor 115; Orphan receptor (695 aa) | ||
 | TMPRSS15 | transmembrane protease, serine 15; Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases (1019 aa) | ||
 | PRSS27 | protease, serine 27 (290 aa) | ||
 | KLK6 | kallikrein-related peptidase 6; Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells [...] (244 aa) | ||
 | PRSS57 | protease, serine, 57 (283 aa) | ||
 | C1S | complement component 1, s subcomponent (688 aa) | ||
 | TMPRSS11B | transmembrane protease, serine 11B; Probable serine protease (By similarity) (416 aa) | ||
 | FLRT2 | fibronectin leucine rich transmembrane protein 2; May have a function in cell adhesion and/or receptor signaling (660 aa) | ||
 | FLRT3 | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling (649 aa) | ||
 | TMPRSS11F | transmembrane protease, serine 11F; Probable serine protease (By similarity) (438 aa) | ||
 | KLK8 | kallikrein-related peptidase 8 (305 aa) | ||
 | KLK7 | kallikrein-related peptidase 7; May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at ’6-Leu-|-Cys-7’, ’16-Tyr-|-Leu-17’, ’25-Phe-|-Tyr-26’ and ’26-Tyr-|-Thr-27’. Could play a role in the activation of precursors to inflammatory cytokines (253 aa) | ||
 | TENM3 | teneurin transmembrane protein 3; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer (By sim [...] (2699 aa) | ||
 | TENM1 | teneurin transmembrane protein 1; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity) (2732 aa) | ||
 | GPR124 | G protein-coupled receptor 124; Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity) (1338 aa) | ||
 | TENM2 | teneurin transmembrane protein 2; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer (2774 aa) | ||
 | KLK11 | kallikrein-related peptidase 11; Possible multifunctional protease. Efficiently cleaves ’bz-Phe-Arg-4-methylcoumaryl-7-amide’, a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues (282 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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