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TRAPPC6A | trafficking protein particle complex 6A; May play a role in vesicular transport during the biogenesis of melanosomes (By similarity) (173 aa) | |||
POLM | polymerase (DNA directed), mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination (494 aa) | |||
SEC14L5 | SEC14-like 5 (S. cerevisiae) (696 aa) | |||
POLB | polymerase (DNA directed), beta; Repair polymerase that plays a key role in base-excision repair. Has 5’-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5’ sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3’ end of the arising single-nucleotide gap. Conducts ’gap-filling’ DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases (335 aa) | |||
TRAPPC8 | trafficking protein particle complex 8; May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (1435 aa) | |||
TRAPPC10 | trafficking protein particle complex 10; May play a role in vesicular transport from endoplasmic reticulum to Golgi (1259 aa) | |||
POLL | polymerase (DNA directed), lambda; Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5’-deoxyribose-5-phosphate lyase (dRP lyase) activity (575 aa) | |||
TRAPPC2L | trafficking protein particle complex 2-like; May play a role in vesicular transport from endoplasmic reticulum to Golgi (140 aa) | |||
TRAPPC1 | trafficking protein particle complex 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi (145 aa) | |||
COG8 | component of oligomeric golgi complex 8; Required for normal Golgi function (By similarity) (612 aa) | |||
RAB1B | RAB1B, member RAS oncogene family; Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (201 aa) | |||
TRAPPC5 | trafficking protein particle complex 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi (188 aa) | |||
TRAPPC6B | trafficking protein particle complex 6B; May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity) (158 aa) | |||
UBC | ubiquitin C (685 aa) | |||
BET3L | BET3 like (S. cerevisiae); May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity) (181 aa) | |||
DNTT | deoxynucleotidyltransferase, terminal; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5’-triphosphate to the 3’-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells (509 aa) | |||
TRAPPC3 | trafficking protein particle complex 3; May play a role in vesicular transport from endoplasmic reticulum to Golgi (180 aa) | |||
RAB1A | RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity (205 aa) | |||
TRAPPC2 | trafficking protein particle complex 2; Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi (174 aa) | |||
PSMC6 | proteasome (prosome, macropain) 26S subunit, ATPase, 6; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (403 aa) | |||
TECPR1 | tectonin beta-propeller repeat containing 1; Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes- acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation (1165 aa) | |||
C5orf44 | chromosome 5 open reading frame 44 (418 aa) | |||
TRAPPC4 | trafficking protein particle complex 4; May play a role in vesicular transport from endoplasmic reticulum to Golgi (219 aa) | |||
TRAPPC2P1 | trafficking protein particle complex 2 pseudogene 1; Prevents transcriptional repression and induction of cell death by ENO1. May play a role in vesicular transport from endoplasmic reticulum to Golgi (140 aa) | |||
ENSG00000260371 | Uncharacterized protein (156 aa) | |||
ENSG00000261576 | Uncharacterized protein (164 aa) |