Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | ACTA2 | actin, alpha 2, smooth muscle, aorta; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (377 aa) | ||
 | ACTR10 | actin-related protein 10 homolog (S. cerevisiae) (417 aa) | ||
 | FSCN3 | fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus); Acts as an actin bundling protein (By similarity) (498 aa) | ||
 | VILL | villin-like; Possible tumor suppressor (856 aa) | ||
 | ACTR1B | ARP1 actin-related protein 1 homolog B, centractin beta (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (376 aa) | ||
 | ACTC1 | actin, alpha, cardiac muscle 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (377 aa) | ||
 | ACTG2 | actin, gamma 2, smooth muscle, enteric; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (376 aa) | ||
 | ACTL9 | actin-like 9 (416 aa) | ||
 | ACTL10 | actin-like 10 (245 aa) | ||
 | ACTG1 | actin, gamma 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (375 aa) | ||
 | ACTRT3 | actin-related protein T3 (372 aa) | ||
 | ACTL7A | actin-like 7A (435 aa) | ||
 | FSCN2 | fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus) (516 aa) | ||
 | ACTB | actin, beta (375 aa) | ||
 | POTEF | POTE ankyrin domain family, member F (1075 aa) | ||
 | ACTA1 | actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (377 aa) | ||
 | ACTR1A | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (376 aa) | ||
 | ACTRT1 | actin-related protein T1 (376 aa) | ||
 | ACTL7B | actin-like 7B (415 aa) | ||
 | ACTL8 | actin-like 8 (366 aa) | ||
 | ACTRT2 | actin-related protein T2 (377 aa) | ||
 | FSCN1 | fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus); Organizes filamentous actin into bundles with a minimum of 4.1-1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (493 aa) | ||
 | POTEJ | POTE ankyrin domain family, member J (1038 aa) | ||
 | POTEI | POTE ankyrin domain family, member I (1075 aa) | ||
 | ACTBL2 | actin, beta-like 2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (By similarity) (376 aa) | ||
 | POTEE | POTE ankyrin domain family member E (1075 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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