node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTA1 | PFN1 | ENSP00000355645 | ENSP00000225655 | actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | profilin 1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR | 0.914 |
ACTA1 | PFN2 | ENSP00000355645 | ENSP00000239940 | actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | profilin 2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG | 0.787 |
ACTA1 | PFN4 | ENSP00000355645 | ENSP00000322170 | actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | profilin family, member 4; Binds to actin and affects the structure of the cytoskeleton (By similarity) | 0.787 |
ACTA1 | TMSB4Y | ENSP00000355645 | ENSP00000284856 | actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | thymosin beta 4, Y-linked; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity) | 0.632 |
ACTB | PFN1 | ENSP00000349960 | ENSP00000225655 | actin, beta | profilin 1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR | 0.997 |
ACTB | PFN2 | ENSP00000349960 | ENSP00000239940 | actin, beta | profilin 2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG | 0.981 |
ACTB | PFN4 | ENSP00000349960 | ENSP00000322170 | actin, beta | profilin family, member 4; Binds to actin and affects the structure of the cytoskeleton (By similarity) | 0.956 |
ACTB | TMSB4Y | ENSP00000349960 | ENSP00000284856 | actin, beta | thymosin beta 4, Y-linked; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity) | 0.826 |
PFN1 | ACTA1 | ENSP00000225655 | ENSP00000355645 | profilin 1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR | actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | 0.914 |
PFN1 | ACTB | ENSP00000225655 | ENSP00000349960 | profilin 1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR | actin, beta | 0.997 |
PFN1 | PFN4 | ENSP00000225655 | ENSP00000322170 | profilin 1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR | profilin family, member 4; Binds to actin and affects the structure of the cytoskeleton (By similarity) | 0.566 |
PFN1 | TMSB4Y | ENSP00000225655 | ENSP00000284856 | profilin 1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR | thymosin beta 4, Y-linked; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity) | 0.466 |
PFN2 | ACTA1 | ENSP00000239940 | ENSP00000355645 | profilin 2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG | actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | 0.787 |
PFN2 | ACTB | ENSP00000239940 | ENSP00000349960 | profilin 2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG | actin, beta | 0.981 |
PFN2 | PFN4 | ENSP00000239940 | ENSP00000322170 | profilin 2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG | profilin family, member 4; Binds to actin and affects the structure of the cytoskeleton (By similarity) | 0.740 |
PFN2 | TMSB4Y | ENSP00000239940 | ENSP00000284856 | profilin 2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG | thymosin beta 4, Y-linked; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity) | 0.466 |
PFN4 | ACTA1 | ENSP00000322170 | ENSP00000355645 | profilin family, member 4; Binds to actin and affects the structure of the cytoskeleton (By similarity) | actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | 0.787 |
PFN4 | ACTB | ENSP00000322170 | ENSP00000349960 | profilin family, member 4; Binds to actin and affects the structure of the cytoskeleton (By similarity) | actin, beta | 0.956 |
PFN4 | PFN1 | ENSP00000322170 | ENSP00000225655 | profilin family, member 4; Binds to actin and affects the structure of the cytoskeleton (By similarity) | profilin 1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR | 0.566 |
PFN4 | PFN2 | ENSP00000322170 | ENSP00000239940 | profilin family, member 4; Binds to actin and affects the structure of the cytoskeleton (By similarity) | profilin 2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG | 0.740 |