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APBB1 APBB1 MMRN1 MMRN1 AVPR1B AVPR1B SERPINA4 SERPINA4 BRS3 BRS3 FFAR2 FFAR2 GPER GPER HTR1F HTR1F APP APP ADCY1 ADCY1 ADRA1D ADRA1D P2RY10 P2RY10 C5AR1 C5AR1 PNOC PNOC NMUR1 NMUR1 EDN2 EDN2 CCL16 CCL16 BDKRB2 BDKRB2 GRM4 GRM4 GNRHR GNRHR ADCY7 ADCY7 POMC POMC C3AR1 C3AR1 AHSG AHSG GRM3 GRM3 NPY1R NPY1R
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
P2RY10purinergic receptor P2Y, G-protein coupled, 10; Putative receptor for purines coupled to G-proteins (339 aa)
GNRHRgonadotropin-releasing hormone receptor; Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle- stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol- calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling (328 aa)
FFAR2free fatty acid receptor 2; Receptor for short chain fatty acids through a G(i)- protein-mediated inhibition of adenylyl cyclase and elevation of intracellular calcium. The rank order of potency for agonists of this receptor is acetate= propionate = butyrate > pentanoate = formate (330 aa)
ADCY7adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase (1080 aa)
POMCproopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol (267 aa)
MMRN1multimerin 1; Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein (1228 aa)
APPamyloid beta (A4) precursor protein (770 aa)
CCL16chemokine (C-C motif) ligand 16; Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES (120 aa)
ADCY1adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning (1119 aa)
GPERG protein-coupled estrogen receptor 1 (375 aa)
SERPINA4serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4; Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein (427 aa)
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on ’Tyr-142’ (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro- apoptosis factors such a [...] (708 aa)
PNOCprepronociceptin; Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development (By similarity) (176 aa)
C3AR1complement component 3a receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production (482 aa)
NMUR1neuromedin U receptor 1; Receptor for the neuromedin-U and neuromedin-S neuropeptides (By similarity) (426 aa)
BDKRB2bradykinin receptor B2; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (391 aa)
HTR1F5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity (366 aa)
C5AR1complement component 5a receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production (350 aa)
NPY1Rneuropeptide Y receptor Y1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid (384 aa)
GRM3glutamate receptor, metabotropic 3; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity (879 aa)
AVPR1Barginine vasopressin receptor 1B (424 aa)
BRS3bombesin-like receptor 3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (399 aa)
EDN2endothelin 2; Endothelins are endothelium-derived vasoconstrictor peptides (178 aa)
GRM4glutamate receptor, metabotropic 4; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity (912 aa)
ADRA1Dadrenoceptor alpha 1D; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium (572 aa)
AHSGalpha-2-HS-glycoprotein; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions (367 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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