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KLHL13 KLHL13 KCTD13 KCTD13 NTAN1 NTAN1 KCTD10 KCTD10 KLHL9 KLHL9 WRNIP1 WRNIP1 SON SON KRT4 KRT4 DDX58 DDX58 BTBD9 BTBD9 HID1 HID1 USP25 USP25 UBC UBC USP21 USP21 PFAS PFAS USP28 USP28 PIP PIP ZG16B ZG16B GMPS GMPS MYO6 MYO6 NEDD8 NEDD8 ANXA1 ANXA1 LYZ LYZ LRIG3 LRIG3 UBE2I UBE2I CROT CROT
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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white nodes:
second shell of interactors
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Predicted Interactions
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USP28ubiquitin specific peptidase 28; Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome- acts by specifically interacting wit [...] (1077 aa)
KCTD10potassium channel tetramerisation domain containing 10; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity) (313 aa)
NEDD8neural precursor cell expressed, developmentally down-regulated 8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (81 aa)
ANXA1annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity (346 aa)
LYZlysozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents (148 aa)
USP25ubiquitin specific peptidase 25; Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both ’Lys-48’- and ’Lys-63’-linked tetraubiquitin chains (1055 aa)
NTAN1N-terminal asparagine amidase; Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N- terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on su [...] (310 aa)
USP21ubiquitin specific peptidase 21; Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at ’Lys-4’, resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (565 aa)
PIPprolactin-induced protein (146 aa)
KCTD13potassium channel tetramerisation domain containing 13; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration (329 aa)
PFASphosphoribosylformylglycinamidine synthase (1338 aa)
UBE2Iubiquitin-conjugating enzyme E2I; Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly- SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at ’Lys-386’ (By similarity) (158 aa)
LRIG3leucine-rich repeats and immunoglobulin-like domains 3; May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity) (1119 aa)
UBCubiquitin C (685 aa)
SONSON DNA binding protein (2426 aa)
KLHL9kelch-like 9 (Drosophila); Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (617 aa)
MYO6myosin VI; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in [...] (1285 aa)
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 58; Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include- 5’- triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5’-triphosphate moiety, blunt-end base pairing at the 5’-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impac [...] (925 aa)
WRNIP1Werner helicase interacting protein 1 (665 aa)
ZG16Bzymogen granule protein 16 homolog B (rat) (208 aa)
BTBD9BTB (POZ) domain containing 9 (612 aa)
HID1HID1 domain containing; May play an important role in the development of cancers in a broad range of tissues (788 aa)
CROTcarnitine O-octanoyltransferase; Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl- CoA, to its corresponding carnitine ester (640 aa)
GMPSguanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division (693 aa)
KLHL13kelch-like 13 (Drosophila) (658 aa)
KRT4keratin 4 (520 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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