node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKMY2 | PARP6 | ENSP00000303570 | ENSP00000287196 | ankyrin repeat and MYND domain containing 2; May be involved in the trafficking of signaling proteins to the cilia (By similarity) | poly (ADP-ribose) polymerase family, member 6 | 0.479 |
ANKMY2 | RPRD1A | ENSP00000303570 | ENSP00000349955 | ankyrin repeat and MYND domain containing 2; May be involved in the trafficking of signaling proteins to the cilia (By similarity) | regulation of nuclear pre-mRNA domain containing 1A; Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle | 0.538 |
ANKMY2 | SURF2 | ENSP00000303570 | ENSP00000361032 | ankyrin repeat and MYND domain containing 2; May be involved in the trafficking of signaling proteins to the cilia (By similarity) | surfeit 2 | 0.461 |
ARIH2 | PARP6 | ENSP00000348769 | ENSP00000287196 | ariadne homolog 2 (Drosophila); E3 ubiquitin-protein ligase mediating ’Lys-48’-and ’Lys- 63’-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis | poly (ADP-ribose) polymerase family, member 6 | 0.416 |
CBS | PARP6 | ENSP00000344460 | ENSP00000287196 | cystathionine-beta-synthase; Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury (By similarity) | poly (ADP-ribose) polymerase family, member 6 | 0.424 |
CBS | PLIN3 | ENSP00000344460 | ENSP00000221957 | cystathionine-beta-synthase; Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury (By similarity) | perilipin 3; Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network | 0.534 |
CBS | UBA5 | ENSP00000344460 | ENSP00000348565 | cystathionine-beta-synthase; Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury (By similarity) | ubiquitin-like modifier activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2 | 0.650 |
HK1 | PARP6 | ENSP00000384774 | ENSP00000287196 | hexokinase 1 | poly (ADP-ribose) polymerase family, member 6 | 0.426 |
HK1 | PLAA | ENSP00000384774 | ENSP00000380460 | hexokinase 1 | phospholipase A2-activating protein; Involved in the maintenance of ubiquitin levels (By similarity) | 0.552 |
HK1 | UBA5 | ENSP00000384774 | ENSP00000348565 | hexokinase 1 | ubiquitin-like modifier activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2 | 0.422 |
NSFL1C | PARP6 | ENSP00000418529 | ENSP00000287196 | NSFL1 (p97) cofactor (p47) | poly (ADP-ribose) polymerase family, member 6 | 0.426 |
NSFL1C | PLAA | ENSP00000418529 | ENSP00000380460 | NSFL1 (p97) cofactor (p47) | phospholipase A2-activating protein; Involved in the maintenance of ubiquitin levels (By similarity) | 0.952 |
NSFL1C | UBA5 | ENSP00000418529 | ENSP00000348565 | NSFL1 (p97) cofactor (p47) | ubiquitin-like modifier activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2 | 0.422 |
PARP6 | ANKMY2 | ENSP00000287196 | ENSP00000303570 | poly (ADP-ribose) polymerase family, member 6 | ankyrin repeat and MYND domain containing 2; May be involved in the trafficking of signaling proteins to the cilia (By similarity) | 0.479 |
PARP6 | ARIH2 | ENSP00000287196 | ENSP00000348769 | poly (ADP-ribose) polymerase family, member 6 | ariadne homolog 2 (Drosophila); E3 ubiquitin-protein ligase mediating ’Lys-48’-and ’Lys- 63’-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis | 0.416 |
PARP6 | CBS | ENSP00000287196 | ENSP00000344460 | poly (ADP-ribose) polymerase family, member 6 | cystathionine-beta-synthase; Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury (By similarity) | 0.424 |
PARP6 | HK1 | ENSP00000287196 | ENSP00000384774 | poly (ADP-ribose) polymerase family, member 6 | hexokinase 1 | 0.426 |
PARP6 | NSFL1C | ENSP00000287196 | ENSP00000418529 | poly (ADP-ribose) polymerase family, member 6 | NSFL1 (p97) cofactor (p47) | 0.426 |
PARP6 | PLAA | ENSP00000287196 | ENSP00000380460 | poly (ADP-ribose) polymerase family, member 6 | phospholipase A2-activating protein; Involved in the maintenance of ubiquitin levels (By similarity) | 0.491 |
PARP6 | PLIN3 | ENSP00000287196 | ENSP00000221957 | poly (ADP-ribose) polymerase family, member 6 | perilipin 3; Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network | 0.428 |