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TOPBP1 | topoisomerase (DNA) II binding protein 1; Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double- stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1- responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR (1522 aa) | |||
ANKRD32 | ankyrin repeat domain 32 (1058 aa) | |||
GLYATL2 | glycine-N-acyltransferase-like 2; Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Conjugates numerous substrates, such as arachidonoyl-CoA and saturated medium and long-chain acyl-CoAs ranging from chain-length C8-0-CoA to C18-0- CoA, to form a variety of N-acylglycines. Shows a preference for monounsaturated fatty acid oleoyl-CoA (C18-1-CoA) as an acyl donor. Does not exhibit any activity toward C22-6-CoA and chenodeoxycholoyl-CoA, nor toward serine or alanine (294 aa) |