node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CENPJ | CEP135 | ENSP00000371308 | ENSP00000257287 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | centrosomal protein 135kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole | 0.997 |
CENPJ | CEP250 | ENSP00000371308 | ENSP00000380661 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | centrosomal protein 250kDa; Probably plays an important role in centrosome cohesion during interphase | 0.905 |
CENPJ | NEURL4 | ENSP00000371308 | ENSP00000382390 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | neuralized homolog 4 (Drosophila); Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers | 0.449 |
CENPJ | SASS6 | ENSP00000371308 | ENSP00000287482 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | spindle assembly 6 homolog (C. elegans); Required for centrosome duplication. Overexpression results in excess foci-bearing centriolar markers | 0.997 |
CENPJ | STIL | ENSP00000371308 | ENSP00000360944 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | SCL/TAL1 interrupting locus; Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 | 0.952 |
CENPJ | TMEM35 | ENSP00000371308 | ENSP00000362021 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | transmembrane protein 35; A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth (By similarity) | 0.869 |
CEP135 | CENPJ | ENSP00000257287 | ENSP00000371308 | centrosomal protein 135kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | 0.997 |
CEP135 | CEP250 | ENSP00000257287 | ENSP00000380661 | centrosomal protein 135kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole | centrosomal protein 250kDa; Probably plays an important role in centrosome cohesion during interphase | 0.920 |
CEP135 | NEURL4 | ENSP00000257287 | ENSP00000382390 | centrosomal protein 135kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole | neuralized homolog 4 (Drosophila); Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers | 0.496 |
CEP135 | SASS6 | ENSP00000257287 | ENSP00000287482 | centrosomal protein 135kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole | spindle assembly 6 homolog (C. elegans); Required for centrosome duplication. Overexpression results in excess foci-bearing centriolar markers | 0.948 |
CEP135 | STIL | ENSP00000257287 | ENSP00000360944 | centrosomal protein 135kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole | SCL/TAL1 interrupting locus; Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 | 0.501 |
CEP135 | UBC | ENSP00000257287 | ENSP00000344818 | centrosomal protein 135kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole | ubiquitin C | 0.629 |
CEP250 | CENPJ | ENSP00000380661 | ENSP00000371308 | centrosomal protein 250kDa; Probably plays an important role in centrosome cohesion during interphase | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | 0.905 |
CEP250 | CEP135 | ENSP00000380661 | ENSP00000257287 | centrosomal protein 250kDa; Probably plays an important role in centrosome cohesion during interphase | centrosomal protein 135kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole | 0.920 |
CEP250 | SASS6 | ENSP00000380661 | ENSP00000287482 | centrosomal protein 250kDa; Probably plays an important role in centrosome cohesion during interphase | spindle assembly 6 homolog (C. elegans); Required for centrosome duplication. Overexpression results in excess foci-bearing centriolar markers | 0.621 |
CEP250 | UBC | ENSP00000380661 | ENSP00000344818 | centrosomal protein 250kDa; Probably plays an important role in centrosome cohesion during interphase | ubiquitin C | 0.851 |
CETN3 | SASS6 | ENSP00000283122 | ENSP00000287482 | centrin, EF-hand protein, 3; Plays a fundamental role in microtubule-organizing center structure and function | spindle assembly 6 homolog (C. elegans); Required for centrosome duplication. Overexpression results in excess foci-bearing centriolar markers | 0.617 |
CETN3 | UBC | ENSP00000283122 | ENSP00000344818 | centrin, EF-hand protein, 3; Plays a fundamental role in microtubule-organizing center structure and function | ubiquitin C | 0.529 |
FBXW5 | NEURL4 | ENSP00000313034 | ENSP00000382390 | F-box and WD repeat domain containing 5 | neuralized homolog 4 (Drosophila); Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers | 0.493 |
FBXW5 | SASS6 | ENSP00000313034 | ENSP00000287482 | F-box and WD repeat domain containing 5 | spindle assembly 6 homolog (C. elegans); Required for centrosome duplication. Overexpression results in excess foci-bearing centriolar markers | 0.823 |