node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NTPCR | THTPA | ENSP00000355587 | ENSP00000288014 | nucleoside-triphosphatase, cancer-related; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency | thiamine triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP) | 0.900 |
NTPCR | TPK1 | ENSP00000355587 | ENSP00000353165 | nucleoside-triphosphatase, cancer-related; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency | thiamin pyrophosphokinase 1; Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate | 0.900 |
NTPCR | UBC | ENSP00000355587 | ENSP00000344818 | nucleoside-triphosphatase, cancer-related; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency | ubiquitin C | 0.795 |
THTPA | NTPCR | ENSP00000288014 | ENSP00000355587 | thiamine triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP) | nucleoside-triphosphatase, cancer-related; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency | 0.900 |
THTPA | TPK1 | ENSP00000288014 | ENSP00000353165 | thiamine triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP) | thiamin pyrophosphokinase 1; Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate | 0.933 |
THTPA | TRMT1L | ENSP00000288014 | ENSP00000356476 | thiamine triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP) | tRNA methyltransferase 1 homolog (S. cerevisiae)-like; May play a role in motor coordination and exploratory behavior (By similarity) | 0.644 |
THTPA | UBA5 | ENSP00000288014 | ENSP00000348565 | thiamine triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP) | ubiquitin-like modifier activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2 | 0.986 |
THTPA | UBC | ENSP00000288014 | ENSP00000344818 | thiamine triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP) | ubiquitin C | 0.729 |
THTPA | USP7 | ENSP00000288014 | ENSP00000343535 | thiamine triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP) | ubiquitin specific peptidase 7 (herpes virus-associated); Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53- dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen pero [...] | 0.644 |
TPK1 | NTPCR | ENSP00000353165 | ENSP00000355587 | thiamin pyrophosphokinase 1; Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate | nucleoside-triphosphatase, cancer-related; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency | 0.900 |
TPK1 | THTPA | ENSP00000353165 | ENSP00000288014 | thiamin pyrophosphokinase 1; Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate | thiamine triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP) | 0.933 |
TRMT1L | THTPA | ENSP00000356476 | ENSP00000288014 | tRNA methyltransferase 1 homolog (S. cerevisiae)-like; May play a role in motor coordination and exploratory behavior (By similarity) | thiamine triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP) | 0.644 |
TRMT1L | UBC | ENSP00000356476 | ENSP00000344818 | tRNA methyltransferase 1 homolog (S. cerevisiae)-like; May play a role in motor coordination and exploratory behavior (By similarity) | ubiquitin C | 0.656 |
UBA5 | THTPA | ENSP00000348565 | ENSP00000288014 | ubiquitin-like modifier activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2 | thiamine triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP) | 0.986 |
UBA5 | UBC | ENSP00000348565 | ENSP00000344818 | ubiquitin-like modifier activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2 | ubiquitin C | 0.740 |
UBC | NTPCR | ENSP00000344818 | ENSP00000355587 | ubiquitin C | nucleoside-triphosphatase, cancer-related; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency | 0.795 |
UBC | THTPA | ENSP00000344818 | ENSP00000288014 | ubiquitin C | thiamine triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP) | 0.729 |
UBC | TRMT1L | ENSP00000344818 | ENSP00000356476 | ubiquitin C | tRNA methyltransferase 1 homolog (S. cerevisiae)-like; May play a role in motor coordination and exploratory behavior (By similarity) | 0.656 |
UBC | UBA5 | ENSP00000344818 | ENSP00000348565 | ubiquitin C | ubiquitin-like modifier activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2 | 0.740 |
UBC | USP7 | ENSP00000344818 | ENSP00000343535 | ubiquitin C | ubiquitin specific peptidase 7 (herpes virus-associated); Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53- dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen pero [...] | 0.999 |