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STRINGSTRING
DRAP1 DRAP1 CTBP2 CTBP2 NEDD8 NEDD8 KLHDC2 KLHDC2 UBC UBC XPO6 XPO6 ZC3H14 ZC3H14 POLDIP3 POLDIP3 XPO5 XPO5 NXF2B NXF2B NXF2 NXF2 NXF1 NXF1 NXF5 NXF5 DDX19B DDX19B NXF3 NXF3 NUP214 NUP214 TPR TPR MCM3AP MCM3AP XPO1 XPO1 RPTN RPTN RAE1 RAE1 ALYREF ALYREF CHM CHM SAC3D1 SAC3D1 GLE1 GLE1 MIF4GD MIF4GD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
MIF4GDMIF4G domain containing; Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation (256 aa)
NEDD8neural precursor cell expressed, developmentally down-regulated 8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (81 aa)
ZC3H14zinc finger CCCH-type containing 14 (736 aa)
POLDIP3polymerase (DNA-directed), delta interacting protein 3 (421 aa)
XPO5exportin 5 (1204 aa)
DDX19BDEAD (Asp-Glu-Ala-Asp) box polypeptide 19B; ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (479 aa)
MCM3APminichromosome maintenance complex component 3 associated protein; May be involved in the nuclear localization pathway of MCM3 (1980 aa)
NXF1nuclear RNA export factor 1; Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (619 aa)
KLHDC2kelch domain containing 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding (406 aa)
XPO6exportin 6; Mediates the nuclear export of actin and profilin-actin complexes in somatic cells (1125 aa)
DRAP1DR1-associated protein 1 (negative cofactor 2 alpha); The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (205 aa)
GLE1GLE1 RNA export mediator homolog (yeast); Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (698 aa)
CTBP2C-terminal binding protein 2; Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity) (985 aa)
RPTNrepetin; Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium (784 aa)
NXF2nuclear RNA export factor 2 (626 aa)
UBCubiquitin C (685 aa)
CHMchoroideremia (Rab escort protein 1); Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Also a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation (653 aa)
NUP214nucleoporin 214kDa; May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (2090 aa)
TPRtranslocated promoter region, nuclear basket protein; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates t [...] (2363 aa)
RAE1RAE1 RNA export 1 homolog (S. pombe); Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton (368 aa)
NXF2Bnuclear RNA export factor 2B; Involved in the export of mRNA from the nucleus to the cytoplasm (626 aa)
NXF3nuclear RNA export factor 3; May function as a tissue-specific nuclear mRNA export factor (531 aa)
SAC3D1SAC3 domain containing 1; Involved in centrosome duplication and mitotic progression (By similarity) (358 aa)
XPO1exportin 1 (CRM1 homolog, yeast); Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) c [...] (1071 aa)
ALYREFAly/REF export factor; Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO [...] (264 aa)
NXF5nuclear RNA export factor 5 (365 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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