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RILP RILP DYNLL1 DYNLL1 HLA-DQA2 HLA-DQA2 DYNLL2 DYNLL2 DYNC1LI2 DYNC1LI2 HLA-DPB1 HLA-DPB1 DYNC1I1 DYNC1I1 DYNC1I2 DYNC1I2 ACTR1B ACTR1B DCTN1 DCTN1 DYNC2LI1 DYNC2LI1 HLA-DRB5 HLA-DRB5 DCTN5 DCTN5 HLA-DRB1 HLA-DRB1 DCTN6 DCTN6 DCTN2 DCTN2 DCTN4 DCTN4 KIFAP3 KIFAP3 ACTR10 ACTR10 HLA-DRA HLA-DRA RACGAP1 RACGAP1 HLA-DMA HLA-DMA HLA-DPA1 HLA-DPA1 HLA-DMB HLA-DMB HLA-DOA HLA-DOA HLA-DOB HLA-DOB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
DCTN6dynactin 6 (190 aa)
HLA-DOAmajor histocompatibility complex, class II, DO alpha (250 aa)
DYNLL2dynein, light chain, LC8-type 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity) (89 aa)
DYNLL1dynein, light chain, LC8-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (89 aa)
ACTR10actin-related protein 10 homolog (S. cerevisiae) (417 aa)
DYNC1LI2dynein, cytoplasmic 1, light intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes (492 aa)
DYNC2LI1dynein, cytoplasmic 2, light intermediate chain 1 (351 aa)
ACTR1BARP1 actin-related protein 1 homolog B, centractin beta (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (376 aa)
DCTN5dynactin 5 (p25) (182 aa)
RILPRab interacting lysosomal protein; Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes (401 aa)
RACGAP1Rac GTPase activating protein 1; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase acti [...] (632 aa)
DYNC1I1dynein, cytoplasmic 1, intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150- glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and k [...] (645 aa)
HLA-DRB1major histocompatibility complex, class II, DR beta 1 (266 aa)
KIFAP3kinesin-associated protein 3; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity) (792 aa)
DCTN1dynactin 1 (1278 aa)
HLA-DMAmajor histocompatibility complex, class II, DM alpha (261 aa)
HLA-DQA2major histocompatibility complex, class II, DQ alpha 2 (255 aa)
HLA-DRB5major histocompatibility complex, class II, DR beta 5 (266 aa)
HLA-DRAmajor histocompatibility complex, class II, DR alpha (254 aa)
DYNC1I2dynein, cytoplasmic 1, intermediate chain 2 (638 aa)
HLA-DOBmajor histocompatibility complex, class II, DO beta (273 aa)
HLA-DPA1major histocompatibility complex, class II, DP alpha 1 (260 aa)
HLA-DMBmajor histocompatibility complex, class II, DM beta (263 aa)
HLA-DPB1major histocompatibility complex, class II, DP beta 1 (258 aa)
DCTN2dynactin 2 (p50); Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (406 aa)
DCTN4dynactin 4 (p62); Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton (467 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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