node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MYBPC3 | MYH1 | ENSP00000442795 | ENSP00000226207 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, heavy chain 1, skeletal muscle, adult; Muscle contraction | 0.734 |
MYBPC3 | MYH10 | ENSP00000442795 | ENSP00000269243 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, heavy chain 10, non-muscle; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2 | 0.720 |
MYBPC3 | MYH11 | ENSP00000442795 | ENSP00000379616 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, heavy chain 11, smooth muscle; Muscle contraction | 0.728 |
MYBPC3 | MYH13 | ENSP00000442795 | ENSP00000252172 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, heavy chain 13, skeletal muscle; Muscle contraction | 0.750 |
MYBPC3 | MYH14 | ENSP00000442795 | ENSP00000262269 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, heavy chain 14, non-muscle | 0.979 |
MYBPC3 | MYH2 | ENSP00000442795 | ENSP00000245503 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, heavy chain 2, skeletal muscle, adult; Muscle contraction. Required for cytoskeleton organization (By similarity) | 0.721 |
MYBPC3 | MYH3 | ENSP00000442795 | ENSP00000226209 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | 0.901 |
MYBPC3 | MYH4 | ENSP00000442795 | ENSP00000255381 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, heavy chain 4, skeletal muscle; Muscle contraction | 0.720 |
MYBPC3 | MYH6 | ENSP00000442795 | ENSP00000348634 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | 0.980 |
MYBPC3 | MYH7 | ENSP00000442795 | ENSP00000347507 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, heavy chain 7, cardiac muscle, beta | 0.972 |
MYBPC3 | MYH8 | ENSP00000442795 | ENSP00000384330 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction | 0.900 |
MYBPC3 | MYH9 | ENSP00000442795 | ENSP00000216181 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, heavy chain 9, non-muscle; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping | 0.879 |
MYBPC3 | MYL1 | ENSP00000442795 | ENSP00000307280 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, light chain 1, alkali; skeletal, fast; Regulatory light chain of myosin. Does not bind calcium | 0.903 |
MYBPC3 | MYL12A | ENSP00000442795 | ENSP00000217652 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, light chain 12A, regulatory, non-sarcomeric; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity) | 0.402 |
MYBPC3 | MYL3 | ENSP00000442795 | ENSP00000292327 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, light chain 3, alkali; ventricular, skeletal, slow; Regulatory light chain of myosin. Does not bind calcium | 0.970 |
MYBPC3 | MYL5 | ENSP00000442795 | ENSP00000383023 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, light chain 5, regulatory | 0.720 |
MYBPC3 | MYL6B | ENSP00000442795 | ENSP00000207437 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, light chain 6B, alkali, smooth muscle and non-muscle; Regulatory light chain of myosin. Does not bind calcium | 0.734 |
MYBPC3 | MYL9 | ENSP00000442795 | ENSP00000279022 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, light chain 9, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion | 0.784 |
MYBPC3 | MYLPF | ENSP00000442795 | ENSP00000325239 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin light chain, phosphorylatable, fast skeletal muscle | 0.769 |
MYBPC3 | MYOM1 | ENSP00000442795 | ENSP00000348821 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myomesin 1; Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent | 0.724 |